TY  - EJOUR
AU  - Park, Bo-yong
AU  - Kebets, Valeria
AU  - Larivière, Sara
AU  - Hettwer, Meike D
AU  - Paquola, Casey
AU  - Rooij, Daan van
AU  - Buitelaar, Jan
AU  - Franke, Barbara
AU  - Hoogman, Martine
AU  - Schmaal, Lianne
AU  - Veltman, Dick J
AU  - Heuvel, Odile van den
AU  - Stein, Dan J
AU  - Andreassen, Ole A
AU  - Ching, Christopher RK
AU  - Turner, Jessica
AU  - Erp, Theo GM van
AU  - Evans, Alan C
AU  - Dagher, Alain
AU  - Thomopoulos, Sophia I
AU  - Thompson, Paul M
AU  - Valk, Sofie L
AU  - Kirschner, Matthias
AU  - Bernhardt, Boris C
TI  - Multilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
M1  - FZJ-2022-00991
PY  - 2021
AB  - It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we assessed i) shared dimensions of alterations in cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression, obsessive-compulsive disorder, bipolar disorder, schizophrenia) and ii) carried out a multiscale neural contextualization, by cross-referencing shared anomalies against cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients and 15,670 controls), we computed a shared disease dimension on cortical morphology using principal component analysis that described a sensory-fugal pattern with paralimbic regions showing the most consistent abnormalities across conditions. The shared disease dimension was closely related to cortical gradients of microstructure and intrinsic connectivity, as well as neurotransmitter systems, specifically serotonin and dopamine. Our findings embed the shared effects of major psychiatric conditions on brain structure in multiple scales of brain organization and may provide novel insights into neural mechanisms into transdiagnostic vulnerability.
LB  - PUB:(DE-HGF)25
UR  - https://juser.fz-juelich.de/record/905768
ER  -