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@ARTICLE{Park:905768,
      author       = {Park, Bo-yong and Kebets, Valeria and Larivière, Sara and
                      Hettwer, Meike D and Paquola, Casey and Rooij, Daan van and
                      Buitelaar, Jan and Franke, Barbara and Hoogman, Martine and
                      Schmaal, Lianne and Veltman, Dick J and Heuvel, Odile van
                      den and Stein, Dan J and Andreassen, Ole A and Ching,
                      Christopher RK and Turner, Jessica and Erp, Theo GM van and
                      Evans, Alan C and Dagher, Alain and Thomopoulos, Sophia I
                      and Thompson, Paul M and Valk, Sofie L and Kirschner,
                      Matthias and Bernhardt, Boris C},
      title        = {{M}ultilevel neural gradients reflect transdiagnostic
                      effects of major psychiatric conditions on cortical
                      morphology},
      reportid     = {FZJ-2022-00991},
      year         = {2021},
      abstract     = {It is increasingly recognized that multiple psychiatric
                      conditions are underpinned by shared neural pathways,
                      affecting similar brain systems. Here, we assessed i) shared
                      dimensions of alterations in cortical morphology across six
                      major psychiatric conditions (autism spectrum disorder,
                      attention deficit/hyperactivity disorder, major depression,
                      obsessive-compulsive disorder, bipolar disorder,
                      schizophrenia) and ii) carried out a multiscale neural
                      contextualization, by cross-referencing shared anomalies
                      against cortical myeloarchitecture and cytoarchitecture, as
                      well as connectome and neurotransmitter organization.
                      Pooling disease-related effects on MRI-based cortical
                      thickness measures across six ENIGMA working groups,
                      including a total of 28,546 participants (12,876 patients
                      and 15,670 controls), we computed a shared disease dimension
                      on cortical morphology using principal component analysis
                      that described a sensory-fugal pattern with paralimbic
                      regions showing the most consistent abnormalities across
                      conditions. The shared disease dimension was closely related
                      to cortical gradients of microstructure and intrinsic
                      connectivity, as well as neurotransmitter systems,
                      specifically serotonin and dopamine. Our findings embed the
                      shared effects of major psychiatric conditions on brain
                      structure in multiple scales of brain organization and may
                      provide novel insights into neural mechanisms into
                      transdiagnostic vulnerability.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      url          = {https://juser.fz-juelich.de/record/905768},
}