000905771 001__ 905771
000905771 005__ 20220131120342.0
000905771 0247_ $$2Handle$$a2128/30509
000905771 037__ $$aFZJ-2022-00994
000905771 1001_ $$0P:(DE-HGF)0$$aBethlehem, Richard AI$$b0$$eCorresponding author
000905771 245__ $$aBraincharts for the human lifespan
000905771 260__ $$c2021
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000905771 3367_ $$2DRIVER$$apreprint
000905771 3367_ $$2BibTeX$$aARTICLE
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000905771 520__ $$aOver the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in brain morphology, in contrast to growth charts for traits such as height and weight. Here, we built an interactive online resource (www.brainchart.io) to quantify individual differences in brain structure from any current or future magnetic resonance imaging (MRI) study, against models of expected age-related trends. With the goal of basing these on the largest and most inclusive dataset, we aggregated MRI data spanning 115 days post-conception through 100 postnatal years, totaling 122,123 scans from 100,071 individuals in over 100 studies across 6 continents. When quantified as centile scores relative to the reference models, individual differences show high validity with non-MRI brain growth estimates and high stability across longitudinal assessment. Centile scores helped identify previously unreported brain developmental milestones and demonstrated increased genetic heritability compared to non-centiled MRI phenotypes. Crucially for the study of brain disorders, centile scores provide a standardised and interpretable measure of deviation that reveals new patterns of neuroanatomical differences across neurological and psychiatric disorders emerging during development and ageing. In sum, brain charts for the human lifespan are an essential first step towards robust, standardised quantification of individual variation and for characterizing deviation from age-related trends. Our global collaborative study …
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000905771 7001_ $$aSeidlitz, Jakob$$b1
000905771 7001_ $$aWhite, Simon R$$b2
000905771 7001_ $$aVogel, Jacob W$$b3
000905771 7001_ $$aAnderson, Kevin M$$b4
000905771 7001_ $$aAdamson, Chris$$b5
000905771 7001_ $$aAdler, Sophie$$b6
000905771 7001_ $$aAlexopoulos, George S$$b7
000905771 7001_ $$aAnagnostou, Evdokia$$b8
000905771 7001_ $$aAreces-Gonzalez, Ariosky$$b9
000905771 7001_ $$aAstle, Duncan E$$b10
000905771 7001_ $$aAuyeung, Bonnie$$b11
000905771 7001_ $$aAyub, Muhammad$$b12
000905771 7001_ $$aBall, Gareth$$b13
000905771 7001_ $$aBaron-Cohen, Simon$$b14
000905771 7001_ $$aBeare, Richard$$b15
000905771 7001_ $$aBedford, Saashi A$$b16
000905771 7001_ $$aBenegal, Vivek$$b17
000905771 7001_ $$aBeyer, Frauke$$b18
000905771 7001_ $$aBae, Jong Bin$$b19
000905771 7001_ $$aBlangero, John$$b20
000905771 7001_ $$aCabez, Manuel Blesa$$b21
000905771 7001_ $$aBoardman, James P$$b22
000905771 7001_ $$aBorzage, Matthew$$b23
000905771 7001_ $$aBosch-Bayard, Jorge F$$b24
000905771 7001_ $$aBourke, Niall$$b25
000905771 7001_ $$aCalhoun, Vince D$$b26
000905771 7001_ $$aChakravarty, Mallar M$$b27
000905771 7001_ $$aChen, Christina$$b28
000905771 7001_ $$aChertavian, Casey$$b29
000905771 7001_ $$aChetelat, Gael$$b30
000905771 7001_ $$aChong, Yap S$$b31
000905771 7001_ $$aCole, James H$$b32
000905771 7001_ $$aCorvin, Aiden$$b33
000905771 7001_ $$aCourchesne, Eric$$b34
000905771 7001_ $$aCrivello, Fabrice$$b35
000905771 7001_ $$aCropley, Vanessa L$$b36
000905771 7001_ $$aCrosbie, Jennifer$$b37
000905771 7001_ $$aCrossley, Nicolas$$b38
000905771 7001_ $$aDelarue, Marion$$b39
000905771 7001_ $$aDesrivieres, Sylvane$$b40
000905771 7001_ $$aDevenyi, Gabriel$$b41
000905771 7001_ $$aBiase, Maria A Di$$b42
000905771 7001_ $$aDolan, Ray$$b43
000905771 7001_ $$aDonald, Kirsten A$$b44
000905771 7001_ $$aDonohoe, Gary$$b45
000905771 7001_ $$aDunlop, Katharine$$b46
000905771 7001_ $$aEdwards, Anthony D$$b47
000905771 7001_ $$aElison, Jed T$$b48
000905771 7001_ $$aEllis, Cameron T$$b49
000905771 7001_ $$aElman, Jeremy A$$b50
000905771 7001_ $$aEyler, Lisa$$b51
000905771 7001_ $$aFair, Damien A$$b52
000905771 7001_ $$aFletcher, Paul C$$b53
000905771 7001_ $$aFonagy, Peter$$b54
000905771 7001_ $$aFranz, Carol E$$b55
000905771 7001_ $$aGalan-Garcia, Lidice$$b56
000905771 7001_ $$aGholipour, Ali$$b57
000905771 7001_ $$aGiedd, Jay$$b58
000905771 7001_ $$aGilmore, John H$$b59
000905771 7001_ $$aGlahn, David C$$b60
000905771 7001_ $$aGoodyer, Ian$$b61
000905771 7001_ $$aGrant, PE$$b62
000905771 7001_ $$aGroenewold, Nynke A$$b63
000905771 7001_ $$aGunning, Faith M$$b64
000905771 7001_ $$aGur, Raquel E$$b65
000905771 7001_ $$aGur, Ruben C$$b66
000905771 7001_ $$aHammill, Christopher F$$b67
000905771 7001_ $$aHansson, Oskar$$b68
000905771 7001_ $$aHedden, Trey$$b69
000905771 7001_ $$aHeinz, Andreas$$b70
000905771 7001_ $$aHenson, Richard$$b71
000905771 7001_ $$aHeuer, Katja$$b72
000905771 7001_ $$aHoare, Jacqueline$$b73
000905771 7001_ $$aHolla, Bharath$$b74
000905771 7001_ $$aHolmes, Avram J$$b75
000905771 7001_ $$aHolt, Rosie$$b76
000905771 7001_ $$aHuang, Hao$$b77
000905771 7001_ $$aIm, Kiho$$b78
000905771 7001_ $$aIpser, Jonathan$$b79
000905771 7001_ $$aJack, Clifford R$$b80
000905771 7001_ $$aJackowski, Andrea P$$b81
000905771 7001_ $$aJia, Tianye$$b82
000905771 7001_ $$aJohnson, Keith A$$b83
000905771 7001_ $$aJones, David T$$b84
000905771 7001_ $$aJones, Peter B$$b85
000905771 7001_ $$aKahn, Rene$$b86
000905771 7001_ $$aKarlsson, Hasse$$b87
000905771 7001_ $$aKarlsson, Linnea$$b88
000905771 7001_ $$aKawashima, Ryuta$$b89
000905771 7001_ $$aKelley, Elizabeth A$$b90
000905771 7001_ $$aKern, Silke$$b91
000905771 7001_ $$aKim, KW$$b92
000905771 7001_ $$aKitzbichler, Manfred G$$b93
000905771 7001_ $$aKremen, William S$$b94
000905771 7001_ $$aLalonde, Francois$$b95
000905771 7001_ $$aLandeau, Brigitte$$b96
000905771 7001_ $$aLee, Subin$$b97
000905771 7001_ $$aLerch, Jason$$b98
000905771 7001_ $$aLewis, John D$$b99
000905771 7001_ $$aLi, Jiao$$b100
000905771 7001_ $$aLiao, Wei$$b101
000905771 7001_ $$aLinares, Deirel P$$b102
000905771 7001_ $$aListon, Conor$$b103
000905771 7001_ $$aLombardo, Michael V$$b104
000905771 7001_ $$aLv, Jinglei$$b105
000905771 7001_ $$aLynch, Charles$$b106
000905771 7001_ $$aMallard, Travis T$$b107
000905771 7001_ $$aMarcelis, Machteld$$b108
000905771 7001_ $$aMarkello, Ross D$$b109
000905771 7001_ $$aMazoyer, Bernard$$b110
000905771 7001_ $$aMcGuire, Philip$$b111
000905771 7001_ $$aMeaney, Michael J$$b112
000905771 7001_ $$aMechelli, Andrea$$b113
000905771 7001_ $$aMedic, Nenad$$b114
000905771 7001_ $$aMisic, Bratislav$$b115
000905771 7001_ $$aMorgan, Sarah E$$b116
000905771 7001_ $$aMothersill, David$$b117
000905771 7001_ $$aNigg, Joel$$b118
000905771 7001_ $$aOng, Marcus QW$$b119
000905771 7001_ $$aOrtinau, Cynthia$$b120
000905771 7001_ $$aOssenkoppele, Rik$$b121
000905771 7001_ $$aOuyang, Minhui$$b122
000905771 7001_ $$aPalaniyappan, Lena$$b123
000905771 7001_ $$aPaly, Leo$$b124
000905771 7001_ $$aPan, Pedro M$$b125
000905771 7001_ $$aPantelis, Christos$$b126
000905771 7001_ $$aPark, Min Tae M$$b127
000905771 7001_ $$aPaus, Tomas$$b128
000905771 7001_ $$aPausova, Zdenka$$b129
000905771 7001_ $$aBinette, Alexa Pichet$$b130
000905771 7001_ $$aPierce, Karen$$b131
000905771 7001_ $$aQian, Xing$$b132
000905771 7001_ $$aQiu, Anqi$$b133
000905771 7001_ $$aQiu, Jiang$$b134
000905771 7001_ $$aRaznahan, Armin$$b135
000905771 7001_ $$aRittman, Timothy$$b136
000905771 7001_ $$aRollins, Caitlin K$$b137
000905771 7001_ $$aRomero-Garcia, Rafael$$b138
000905771 7001_ $$aRonan, Lisa$$b139
000905771 7001_ $$aRosenberg, Monica D$$b140
000905771 7001_ $$aRowitch, David H$$b141
000905771 7001_ $$aSalum, Giovanni A$$b142
000905771 7001_ $$aSatterthwaite, Theodore D$$b143
000905771 7001_ $$0P:(DE-Juel1)188324$$aSchaare, Lina$$b144$$ufzj
000905771 7001_ $$aSchachar, Russell J$$b145
000905771 7001_ $$aScholl, Michael$$b146
000905771 7001_ $$aSchultz, Aaron P$$b147
000905771 7001_ $$aSchumann, Gunter$$b148
000905771 7001_ $$aSharp, David$$b149
000905771 8564_ $$uhttps://juser.fz-juelich.de/record/905771/files/2021.06.08.447489.full.pdf$$yOpenAccess
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