000905773 001__ 905773
000905773 005__ 20220131120342.0
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000905773 1001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L$$b0$$eCorresponding author$$ufzj
000905773 245__ $$aGenetic and phylogenetic uncoupling of structure and function in human transmodal cortex
000905773 260__ $$c2021
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000905773 520__ $$aBrain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in non-human primates had a similar spatial distribution, but we observed an increased coupling between structure and function in association regions in macaques relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social cognition and autobiographical memory. Our findings establish the genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex, culturally embedded forms of cognition.
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000905773 7001_ $$aXu, Ting$$b1
000905773 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b2$$ufzj
000905773 7001_ $$aPark, Bo-yong$$b3
000905773 7001_ $$aBethlehem, Richard AI$$b4
000905773 7001_ $$aWael, Reinder Vos de$$b5
000905773 7001_ $$aRoyer, Jessica$$b6
000905773 7001_ $$aMasouleh, Shahrzad Kharabian$$b7
000905773 7001_ $$aBayrak, Şeyma$$b8
000905773 7001_ $$aKochunov, Peter$$b9
000905773 7001_ $$aYeo, BT Thomas$$b10
000905773 7001_ $$aMargulies, Daniel$$b11
000905773 7001_ $$aSmallw, Jonathan$$b12
000905773 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B$$b13$$ufzj
000905773 7001_ $$aBernhardt, Boris C$$b14
000905773 8564_ $$uhttps://juser.fz-juelich.de/record/905773/files/2021.06.08.447522.full.pdf$$yOpenAccess
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000905773 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b13$$kFZJ
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000905773 9141_ $$y2021
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