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@ARTICLE{Valk:905773,
      author       = {Valk, Sofie L and Xu, Ting and Paquola, Casey and Park,
                      Bo-yong and Bethlehem, Richard AI and Wael, Reinder Vos de
                      and Royer, Jessica and Masouleh, Shahrzad Kharabian and
                      Bayrak, Şeyma and Kochunov, Peter and Yeo, BT Thomas and
                      Margulies, Daniel and Smallw, Jonathan and Eickhoff, Simon B
                      and Bernhardt, Boris C},
      title        = {{G}enetic and phylogenetic uncoupling of structure and
                      function in human transmodal cortex},
      reportid     = {FZJ-2022-00996},
      year         = {2021},
      abstract     = {Brain structure scaffolds intrinsic function, supporting
                      cognition and ultimately behavioral flexibility. However, it
                      remains unclear how a static, genetically controlled
                      architecture supports flexible cognition and behavior. Here,
                      we synthesize genetic, phylogenetic and cognitive analyses
                      to understand how the macroscale organization of
                      structure-function coupling across the cortex can inform its
                      role in cognition. In humans, structure-function coupling
                      was highest in regions of unimodal cortex and lowest in
                      transmodal cortex, a pattern that was mirrored by a reduced
                      alignment with heritable connectivity profiles.
                      Structure-function uncoupling in non-human primates had a
                      similar spatial distribution, but we observed an increased
                      coupling between structure and function in association
                      regions in macaques relative to humans. Meta-analysis
                      suggested regions with the least genetic control (low
                      heritable correspondence and different across primates) are
                      linked to social cognition and autobiographical memory. Our
                      findings establish the genetic and evolutionary uncoupling
                      of structure and function in different transmodal systems
                      may support the emergence of complex, culturally embedded
                      forms of cognition.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      url          = {https://juser.fz-juelich.de/record/905773},
}