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000905777 0247_ $$2Handle$$a2128/30501
000905777 037__ $$aFZJ-2022-01000
000905777 1001_ $$0P:(DE-HGF)0$$aHong, Seok-Jun$$b0$$eCorresponding author
000905777 245__ $$aA convergent structure-function substrate of cognitive imbalances in autism
000905777 260__ $$c2021
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000905777 520__ $$aAutism is a common neurodevelopmental condition characterized by substantial phenotypic heterogeneity, which hinders diagnosis, research, and intervention. A leading example can be found in marked imbalances in language and perceptual skills, where deficits in one domain often co-exist with normal or even superior performance in the other domain. The current work capitalized on multiple data analytics including data-driven subtyping and dimensional approaches to quantify cognitive imbalances in multi-site datasets of individuals diagnosed with autism spectrum disorder (ASD) and neurotypical controls, and assessed structural and functional brain network substrates. Studying cognitive dimensions as well as multimodal neuroimaging signatures in 155 ASD and 151 neurotypical individuals, we observed robust evidence for a structure-function substrate of cognitive imbalances in ASD. Specifically, ASD presented with marked imbalances in cognitive profiles relative to neurotypical controls, characterized by verbal to non-verbal intelligence discrepancy. Different analytical approaches including subtyping and dimensional regression methods converged in showing that these imbalances were reflected in atypical cortical thickening and functional integration of language networks, alongside sensory and higher cognitive networks. Phenotypic findings could be replicated in an independent sample of 325 ASD and 569 neurotypical controls. Although verbal and non-verbal intelligence are currently considered as specifiers unrelated to the categorical diagnosis of autism, our results show that intelligence disparities are accentuated in ASD …
000905777 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000905777 7001_ $$aLaurent, Mottron$$b1
000905777 7001_ $$aPark, Bo-yong$$b2
000905777 7001_ $$aBenkarim, Oualid$$b3
000905777 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie Louise$$b4$$ufzj
000905777 7001_ $$aPaquola, Casey$$b5
000905777 7001_ $$aLarivière, Sara$$b6
000905777 7001_ $$aWael, Reinder Vos de$$b7
000905777 7001_ $$aDegré-Pelletier, Janie$$b8
000905777 7001_ $$aSoulieres, Isabelle$$b9
000905777 7001_ $$aRamphal, Bruce$$b10
000905777 7001_ $$aMargolis, Amy$$b11
000905777 7001_ $$aMilham, Michael$$b12
000905777 7001_ $$aMartino, Adriana Di$$b13
000905777 7001_ $$aBernhardt, Boris$$b14
000905777 8564_ $$uhttps://juser.fz-juelich.de/record/905777/files/2021.01.14.426284.full.pdf$$yOpenAccess
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000905777 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173843$$aForschungszentrum Jülich$$b4$$kFZJ
000905777 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000905777 9141_ $$y2021
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000905777 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
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