000905779 001__ 905779
000905779 005__ 20220131120342.0
000905779 0247_ $$2Handle$$a2128/30520
000905779 037__ $$aFZJ-2022-01002
000905779 1001_ $$0P:(DE-Juel1)176971$$aKraljevic, Nevena$$b0$$eCorresponding author$$ufzj
000905779 245__ $$aBehavioral, Anatomical and Genetic Convergence of Affect and Cognition in Superior Frontal Cortex
000905779 260__ $$c2021
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000905779 520__ $$aAffective experience and cognitive abilities are key human traits that are interrelated in behavior and brain. Individual variation of affective and cognitive traits, as well as brain structure, has been shown to partly underlie genetic effects. However, to what extent affect and cognition have a shared genetic relationship with local brain structure is incompletely understood. Here we studied phenotypic and genetic correlations of cognitive and affective traits in behavior and brain structure (cortical thickness, surface area and subcortical volumes) in the twin-based Human Connectome Project sample (N = 1091). Both affective and cognitive trait scores were highly heritable and showed significant phenotypic correlation on the behavioral level. Cortical thickness in the left superior frontal cortex showed a phenotypic association with both affect and cognition, which was driven by shared genetic effects. Quantitative functional decoding of this region yielded associations with cognitive and emotional functioning. This study provides a multi-level approach to study the association between affect and cognition and suggests a convergence of both in superior frontal cortical thickness.
000905779 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000905779 7001_ $$aSchaare, H Lina$$b1
000905779 7001_ $$aEickhoff, Simon B$$b2
000905779 7001_ $$aKochunov, Peter$$b3
000905779 7001_ $$aYeo, BT Thomas$$b4
000905779 7001_ $$aMasouleh, Shahrzad Kharabian$$b5
000905779 7001_ $$aValk, Sofie L$$b6
000905779 8564_ $$uhttps://juser.fz-juelich.de/record/905779/files/2020.12.03.401414.full.pdf$$yOpenAccess
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000905779 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)176971$$aForschungszentrum Jülich$$b0$$kFZJ
000905779 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000905779 9141_ $$y2021
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000905779 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
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