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@ARTICLE{Kraljevic:905779,
      author       = {Kraljevic, Nevena and Schaare, H Lina and Eickhoff, Simon B
                      and Kochunov, Peter and Yeo, BT Thomas and Masouleh,
                      Shahrzad Kharabian and Valk, Sofie L},
      title        = {{B}ehavioral, {A}natomical and {G}enetic {C}onvergence of
                      {A}ffect and {C}ognition in {S}uperior {F}rontal {C}ortex},
      reportid     = {FZJ-2022-01002},
      year         = {2021},
      abstract     = {Affective experience and cognitive abilities are key human
                      traits that are interrelated in behavior and brain.
                      Individual variation of affective and cognitive traits, as
                      well as brain structure, has been shown to partly underlie
                      genetic effects. However, to what extent affect and
                      cognition have a shared genetic relationship with local
                      brain structure is incompletely understood. Here we studied
                      phenotypic and genetic correlations of cognitive and
                      affective traits in behavior and brain structure (cortical
                      thickness, surface area and subcortical volumes) in the
                      twin-based Human Connectome Project sample (N = 1091). Both
                      affective and cognitive trait scores were highly heritable
                      and showed significant phenotypic correlation on the
                      behavioral level. Cortical thickness in the left superior
                      frontal cortex showed a phenotypic association with both
                      affect and cognition, which was driven by shared genetic
                      effects. Quantitative functional decoding of this region
                      yielded associations with cognitive and emotional
                      functioning. This study provides a multi-level approach to
                      study the association between affect and cognition and
                      suggests a convergence of both in superior frontal cortical
                      thickness.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      url          = {https://juser.fz-juelich.de/record/905779},
}