%0 Journal Article
%A Kaulen, Nicolas
%A Rajkumar, Ravichandran
%A Régio Brambilla, Cláudia
%A Mauler, Jörg
%A Ramkiran, Shukti
%A Orth, Linda
%A Sbaihat, Hasan
%A Lang, Markus
%A Wyss, Christine
%A Rota Kops, Elena
%A Scheins, Jürgen
%A Neumaier, Bernd
%A Ermert, Johannes
%A Herzog, Hans
%A Langen, Karl-Joseph
%A Lerche, Christoph
%A Shah, N. J.
%A Veselinović, Tanja
%A Neuner, Irene
%T mGluR 5 and GABA A receptor‐specific parametric PET atlas construction— PET / MR data processing pipeline, validation, and application
%J Human brain mapping
%V 43
%N 7
%@ 1065-9471
%C New York, NY
%I Wiley-Liss
%M FZJ-2022-01095
%P 2148-2163
%D 2022
%X The glutamate and γ-aminobutyric acid neuroreceptor subtypes mGluR5 and GABAA are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BPND), and total distribution volume (VT) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and MR data. The pipeline was applied to [11C]ABP688-PET/MR (13 healthy male non-smokers, 26.6 ± 7.0 years) and [11C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as VT and BPND atlases of mGluR5 and GABAA, were generated from these data. The maps were validated by assessing the percent error δ from warped space to native space in a selection of brain regions. We verified that the average δABP = 3.0 ± 1.0% and δFMZ = 3.8 ± 1.4% were lower than the expected variabilities σ of the tracers (σABP = 4.0%–16.0%, σFMZ = 3.9%–9.5%). An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [15O]H2O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposed pipeline is a viable tool for the construction of standardized PET data distributions.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000746511800001
%R 10.1002/hbm.25778
%U https://juser.fz-juelich.de/record/905895