TY  - JOUR
AU  - Kaulen, Nicolas
AU  - Rajkumar, Ravichandran
AU  - Régio Brambilla, Cláudia
AU  - Mauler, Jörg
AU  - Ramkiran, Shukti
AU  - Orth, Linda
AU  - Sbaihat, Hasan
AU  - Lang, Markus
AU  - Wyss, Christine
AU  - Rota Kops, Elena
AU  - Scheins, Jürgen
AU  - Neumaier, Bernd
AU  - Ermert, Johannes
AU  - Herzog, Hans
AU  - Langen, Karl-Joseph
AU  - Lerche, Christoph
AU  - Shah, N. J.
AU  - Veselinović, Tanja
AU  - Neuner, Irene
TI  - mGluR 5 and GABA A receptor‐specific parametric PET atlas construction— PET / MR data processing pipeline, validation, and application
JO  - Human brain mapping
VL  - 43
IS  - 7
SN  - 1065-9471
CY  - New York, NY
PB  - Wiley-Liss
M1  - FZJ-2022-01095
SP  - 2148-2163
PY  - 2022
AB  - The glutamate and γ-aminobutyric acid neuroreceptor subtypes mGluR5 and GABAA are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BPND), and total distribution volume (VT) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and MR data. The pipeline was applied to [11C]ABP688-PET/MR (13 healthy male non-smokers, 26.6 ± 7.0 years) and [11C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as VT and BPND atlases of mGluR5 and GABAA, were generated from these data. The maps were validated by assessing the percent error δ from warped space to native space in a selection of brain regions. We verified that the average δABP = 3.0 ± 1.0% and δFMZ = 3.8 ± 1.4% were lower than the expected variabilities σ of the tracers (σABP = 4.0%–16.0%, σFMZ = 3.9%–9.5%). An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [15O]H2O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposed pipeline is a viable tool for the construction of standardized PET data distributions.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000746511800001
DO  - DOI:10.1002/hbm.25778
UR  - https://juser.fz-juelich.de/record/905895
ER  -