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@ARTICLE{Kaulen:905895,
      author       = {Kaulen, Nicolas and Rajkumar, Ravichandran and Régio
                      Brambilla, Cláudia and Mauler, Jörg and Ramkiran, Shukti
                      and Orth, Linda and Sbaihat, Hasan and Lang, Markus and
                      Wyss, Christine and Rota Kops, Elena and Scheins, Jürgen
                      and Neumaier, Bernd and Ermert, Johannes and Herzog, Hans
                      and Langen, Karl-Joseph and Lerche, Christoph and Shah, N.
                      J. and Veselinović, Tanja and Neuner, Irene},
      title        = {m{G}lu{R} 5 and {GABA} {A} receptor‐specific parametric
                      {PET} atlas construction— {PET} / {MR} data processing
                      pipeline, validation, and application},
      journal      = {Human brain mapping},
      volume       = {43},
      number       = {7},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2022-01095},
      pages        = {2148-2163},
      year         = {2022},
      abstract     = {The glutamate and γ-aminobutyric acid neuroreceptor
                      subtypes mGluR5 and GABAA are hypothesized to be involved in
                      the development of a variety of psychiatric diseases.
                      However, detailed information relating to their in vivo
                      distribution is generally unavailable. Maps of such
                      distributions could potentially aid clinical studies by
                      providing a reference for the normal distribution of
                      neuroreceptors and may also be useful as covariates in
                      advanced functional magnetic resonance imaging (MR) studies.
                      In this study, we propose a comprehensive processing
                      pipeline for the construction of standard space, in vivo
                      distributions of non-displaceable binding potential (BPND),
                      and total distribution volume (VT) based on simultaneously
                      acquired bolus-infusion positron emission tomography (PET)
                      and MR data. The pipeline was applied to [11C]ABP688-PET/MR
                      (13 healthy male non-smokers, 26.6 ± 7.0 years) and
                      [11C]Flumazenil-PET/MR (10 healthy males, 25.8
                      ± 3.0 years) data. Activity concentration templates, as
                      well as VT and BPND atlases of mGluR5 and GABAA, were
                      generated from these data. The maps were validated by
                      assessing the percent error δ from warped space to native
                      space in a selection of brain regions. We verified that the
                      average δABP = 3.0 $± 1.0\%$ and δFMZ = 3.8
                      $± 1.4\%$ were lower than the expected variabilities σ
                      of the tracers (σABP $= 4.0\%–16.0\%,$ σFMZ
                      $= 3.9\%–9.5\%).$ An evaluation of PET-to-PET
                      registrations based on the new maps showed higher
                      registration accuracy compared to registrations based on the
                      commonly used [15O]H2O-template distributed with SPM12.
                      Thus, we conclude that the resulting maps can be used for
                      further research and the proposed pipeline is a viable tool
                      for the construction of standardized PET data
                      distributions.},
      cin          = {INM-11 / INM-4 / JARA-BRAIN / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-11-20170113 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)VDB1046 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000746511800001},
      doi          = {10.1002/hbm.25778},
      url          = {https://juser.fz-juelich.de/record/905895},
}