Home > Publications database > mGluR 5 and GABA A receptor‐specific parametric PET atlas construction— PET / MR data processing pipeline, validation, and application > print

001     905895
005     20230522125345.0
024 7 _ |a 10.1002/hbm.25778
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024 7 _ |a 1065-9471
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024 7 _ |a 1097-0193
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037 _ _ |a FZJ-2022-01095
082 _ _ |a 610
100 1 _ |a Kaulen, Nicolas
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245 _ _ |a mGluR 5 and GABA A receptor‐specific parametric PET atlas construction— PET / MR data processing pipeline, validation, and application
260 _ _ |a New York, NY
|c 2022
|b Wiley-Liss
336 7 _ |a article
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520 _ _ |a The glutamate and γ-aminobutyric acid neuroreceptor subtypes mGluR5 and GABAA are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non-displaceable binding potential (BPND), and total distribution volume (VT) based on simultaneously acquired bolus-infusion positron emission tomography (PET) and MR data. The pipeline was applied to [11C]ABP688-PET/MR (13 healthy male non-smokers, 26.6 ± 7.0 years) and [11C]Flumazenil-PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as VT and BPND atlases of mGluR5 and GABAA, were generated from these data. The maps were validated by assessing the percent error δ from warped space to native space in a selection of brain regions. We verified that the average δABP = 3.0 ± 1.0% and δFMZ = 3.8 ± 1.4% were lower than the expected variabilities σ of the tracers (σABP = 4.0%–16.0%, σFMZ = 3.9%–9.5%). An evaluation of PET-to-PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [15O]H2O-template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposed pipeline is a viable tool for the construction of standardized PET data distributions.
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700 1 _ |a Rajkumar, Ravichandran
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700 1 _ |a Régio Brambilla, Cláudia
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700 1 _ |a Mauler, Jörg
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700 1 _ |a Ramkiran, Shukti
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700 1 _ |a Orth, Linda
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700 1 _ |a Sbaihat, Hasan
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700 1 _ |a Lang, Markus
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700 1 _ |a Wyss, Christine
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700 1 _ |a Rota Kops, Elena
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700 1 _ |a Scheins, Jürgen
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700 1 _ |a Neumaier, Bernd
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700 1 _ |a Ermert, Johannes
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700 1 _ |a Herzog, Hans
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700 1 _ |a Langen, Karl-Joseph
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700 1 _ |a Lerche, Christoph
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700 1 _ |a Shah, N. J.
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700 1 _ |a Veselinović, Tanja
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700 1 _ |a Neuner, Irene
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773 _ _ |a 10.1002/hbm.25778
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856 4 _ |u https://juser.fz-juelich.de/record/905895/files/1200177349_MDPL_K10449_Invoice.pdf
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