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@ARTICLE{Blenau:906146,
      author       = {Blenau, Wolfgang and Bremer, Anna-Sophie and Schwietz,
                      Yannik and Friedrich, Daniel and Ragionieri, Lapo and
                      Predel, Reinhard and Balfanz, Sabine and Baumann, Arnd},
      title        = {{P}a{O}ctβ2{R}: {I}dentification and {F}unctional
                      {C}haracterization of an {O}ctopamine {R}eceptor
                      {A}ctivating {A}denylyl {C}yclase {A}ctivity in the
                      {A}merican {C}ockroach {P}eriplaneta americana},
      journal      = {International journal of molecular sciences},
      volume       = {23},
      number       = {3},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2022-01259},
      pages        = {1677 -},
      year         = {2022},
      abstract     = {Biogenic amines constitute an important group of
                      neuroactive substances that control and modulate various
                      neural circuits. These small organic compounds engage
                      members of the guanine nucleotide-binding protein coupled
                      receptor (GPCR) superfamily to evoke specific cellular
                      responses. In addition to dopamine- and 5-hydroxytryptamine
                      (serotonin) receptors, arthropods express receptors that are
                      activated exclusively by tyramine and octopamine. These
                      phenolamines functionally substitute the noradrenergic
                      system of vertebrates Octopamine receptors that are the
                      focus of this study are classified as either α- or
                      β-adrenergic-like. Knowledge on these receptors is scarce
                      for the American cockroach (Periplaneta americana). So far,
                      only an α–adrenergic-like octopamine receptor that
                      primarily causes Ca2+ release from intracellular stores has
                      been studied from the cockroach (PaOctα1R). Here we
                      succeeded in cloning a gene from cockroach brain tissue that
                      encodes a β-adrenergic-like receptor and leads to cAMP
                      production upon activation. Notably, the receptor is
                      100-fold more selective for octopamine than for tyramine. A
                      series of synthetic antagonists selectively block receptor
                      activity with epinastine being the most potent.
                      Bioinformatics allowed us to identify a total of 19 receptor
                      sequences that build the framework of the biogenic amine
                      receptor clade in the American cockroach. Phylogenetic
                      analyses using these sequences and receptor sequences from
                      model organisms showed that the newly cloned gene is an
                      β2-adrenergic-like octopamine receptor. The functional
                      characterization of PaOctβ2R and the bioinformatics data
                      uncovered that the monoaminergic receptor family in the
                      hemimetabolic P. americana is similarly complex as in
                      holometabolic model insects like Drosophila melanogaster and
                      the honeybee, Apis mellifera. Thus, investigating these
                      receptors in detail may contribute to a better understanding
                      of monoaminergic signaling in insect behavior and
                      physiology.},
      cin          = {IBI-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-1-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35163598},
      UT           = {WOS:000755707900001},
      doi          = {10.3390/ijms23031677},
      url          = {https://juser.fz-juelich.de/record/906146},
}