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@ARTICLE{Ferrea:906227,
author = {Ferrea, Stefano and Junker, Frederick Benjamin and
Hartmann, Christian Johannes and Dinkelbach, Lars and
Eickhoff, Simon B. and Moldovan, Alexia Sabine and
Südmeyer, Martin and Schnitzler, Alfons and Schmidt-Wilcke,
Tobias},
title = {{B}rain volume patterns in corticobasal syndrome versus
idiopathic {P}arkinson's disease},
journal = {Journal of neuroimaging},
volume = {32},
number = {4},
issn = {1051-2284},
address = {Berlin [u.a.]},
publisher = {Wiley-Blackwell},
reportid = {FZJ-2022-01305},
pages = {720-727},
year = {2022},
abstract = {AbstractBackground and purpose: Patients with a
corticobasal syndrome (CBS) present a rare form of atypical
parkinsonism characterized by asymmetric clinical symptoms
and progressive motor and nonmotor impairment, such as
apraxia, alien limb phenomenon, aphasia, myoclonus,
dystonia, and cognitive impairment. At early stages,
clinical differentiation between CBS and idiopathic
Parkinson's disease (IPD) can be challenging.Methods: Using
high-resolution T1-weighted images and voxel-based
morphometry (VBM), we sought to identify disease-specific
patterns of brain atrophy in a small sample of CBS and IPD
patients at early stages of disease. We acquired MR images
of 17 patients diagnosed with CBS and compared them with MR
images of 17 subjects affected by IPD. Images were
preprocessed and analyzed using VBM.Results: When compared
to each other, the CBS and IPD patients of our cohort showed
differences in regional gray and white matter volume
depending on the diagnosis, specifically in the superior
longitudinal fascicle.Conclusions: In our small patients'
group, VBM was able to detect changes in regional gray and
white matter volume between patients affected by CBS and
patients with IPD as early as 1.5-2 years after the onset of
the first motor symptoms.Keywords: Corticobasal syndrome;
brain atrophy; idiopathic Parkinson syndrome; voxel-based
morphometry.},
cin = {INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
pid = {G:(DE-HGF)POF4-5252},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35099094},
UT = {WOS:000749658000001},
doi = {10.1111/jon.12971},
url = {https://juser.fz-juelich.de/record/906227},
}