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001     906426
005     20230123110601.0
024 7 _ |a 10.1016/j.neuroimage.2022.119014
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100 1 _ |a Shah, N. J.
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245 _ _ |a A Novel MRI-Based Quantitative Water Content Atlas of the Human Brain
260 _ _ |a Orlando, Fla.
|c 2022
|b Academic Press
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520 _ _ |a The measurement of quantitative, tissue-specific MR properties, e.g., water content, longitudinal relaxation time (T1) and effective transverse relaxation time (T2*), using quantitative MRI at a clinical field strength (1.5 T to 3T) is a well-explored topic. However, none of the commonly used standard brain atlases, such as MNI or JHU, provide quantitative information. Within the framework of quantitative MRI of the brain, this work reports on the development of the first quantitative brain atlas for tissue water content at 3T. A methodology to create this quantitative atlas of in vivo brain water content based on healthy volunteers is presented, and preliminary, practical examples of its potential applications are also shown.Established methods for the fast and reliable measurement of the absolute water content were used to achieve high precision and accuracy. Water content and T2* were mapped based on two different methods: an intermediate-TR, two-point method and a long-TR, single-scan method. Twenty healthy subjects (age 25.3 ± 2.5 years) were examined with these quantitative imaging protocols. The images were normalised to MNI stereotactic coordinates, and water content atlases of healthy volunteers were created for each method and compared. Regions-of-interest were generated with the help of a standard MNI template, and water content values averaged across the ROIs were compared to water content values from the literature.Finally, in order to demonstrate the strength of quantitative MRI, water content maps from patients with pathological changes in the brain due to stroke, tumour (glioblastoma) and multiple sclerosis were voxel-wise compared to the healthy brain.The water content atlases were largely independent of the method used to acquire the individual water maps. Global grey matter and white matter water content values between the methods agreed with each other to within 0.5 %. The feasibility of detecting abnormal water content in the brains of patients based on comparison to a healthy brain water content atlas was demonstrated.In summary, the first quantitative water content brain atlas in vivo has been developed and a voxel-wise assessment of pathology-related changes in the brain water content has been performed. These results suggest that qMRI, in combination with a water content atlas, allows for a quantitative interpretation of changes due to disease and could be used for disease monitoring.
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700 1 _ |a Abbas, Zaheer
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700 1 _ |a Ridder, Dominik
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700 1 _ |a Zimmermann, Markus
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700 1 _ |a Oros-Peusquens, Ana-Maria
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773 _ _ |a 10.1016/j.neuroimage.2022.119014
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856 4 _ |u https://juser.fz-juelich.de/record/906426/files/Invoice_OAD0000190778.pdf
856 4 _ |y OpenAccess
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