TY  - JOUR
AU  - Liu, Jingjin
AU  - Veldeman, Michael
AU  - Höllig, Anke
AU  - Nolte, Kay
AU  - Liebenstund, Lisa
AU  - Willuweit, Antje
AU  - Langen, Karl-Josef
AU  - Rossaint, Rolf
AU  - Coburn, Mark
TI  - Post-stroke treatment with argon preserved neurons and attenuated microglia/macrophage activation long-termly in a rat model of transient middle cerebral artery occlusion (tMCAO)
JO  - Scientific reports
VL  - 12
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - FZJ-2022-01465
SP  - 691
PY  - 2022
AB  - In a previous study from our group, argon has shown to significantly attenuate brain injury, reduce brain inflammation and enhance M2 microglia/macrophage polarization until 7 days after ischemic stroke. However, the long-term effects of argon have not been reported thus far. In the present study, we analyzed the underlying neuroprotective effects and potential mechanisms of argon, up to 30 days after ischemic stroke. Argon administration with a 3 h delay after stroke onset and 1 h after reperfusion demonstrated long-term neuroprotective effect by preserving the neurons at the ischemic boundary zone 30 days after stroke. Furthermore, the excessive microglia/macrophage activation in rat brain was reduced by argon treatment 30 days after ischemic insult. However, long-lasting neurological improvement was not detectable. More sensorimotor functional measures, age- and disease-related models, as well as further histological and molecular biological analyses will be needed to extend the understanding of argon’s neuroprotective effects and mechanism of action after ischemic stroke.
LB  - PUB:(DE-HGF)16
C6  - 35027642
UR  - <Go to ISI:>//WOS:000742412100008
DO  - DOI:10.1038/s41598-021-04666-x
UR  - https://juser.fz-juelich.de/record/906462
ER  -