TY - JOUR
AU - Pollok, Tania M.
AU - Kaiser, Anna
AU - Kraaijenvanger, Eline J.
AU - Monninger, Maximilian
AU - Brandeis, Daniel
AU - Banaschewski, Tobias
AU - Eickhoff, Simon B.
AU - Holz, Nathalie E.
TI - Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects
JO - Neuroscience & biobehavioral reviews
VL - 135
SN - 0149-7634
CY - Amsterdam [u.a.]
PB - Elsevier Science
M1 - FZJ-2022-01478
SP - 104589
PY - 2022
AB - Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood estimation was used to conduct a coordinate-based meta-analysis of gray matter volume (GMV) alterations associated with ELAs, including sub-analyses for different age groups and maltreatment as specific ELA-type. The analyses uncovered a convergence of pooled ELA-effects on GMV in the right hippocampus and amygdala and the left inferior frontal gyrus, age-specific effects for the right amygdala and hippocampus in children and adolescents, and maltreatment-specific effects for the right perigenual anterior cingulate cortex in adults. These results reveal a possible underlying commonality in the impact of adversity and also point to specific age and maltreatment effects. They suggest neural markers of ELAs in regions involved in socio-emotional functioning and stress regulation, with the potential to be used as targets for interventions designed to buffer or reverse harmful ELA-effects.
LB - PUB:(DE-HGF)16
C6 - pmid:35189164
UR - <Go to ISI:>//WOS:000819835100003
DO - DOI:10.1016/j.neubiorev.2022.104589
UR - https://juser.fz-juelich.de/record/906475
ER -