TY  - JOUR
AU  - Pollok, Tania M.
AU  - Kaiser, Anna
AU  - Kraaijenvanger, Eline J.
AU  - Monninger, Maximilian
AU  - Brandeis, Daniel
AU  - Banaschewski, Tobias
AU  - Eickhoff, Simon B.
AU  - Holz, Nathalie E.
TI  - Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects
JO  - Neuroscience & biobehavioral reviews
VL  - 135
SN  - 0149-7634
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2022-01478
SP  - 104589
PY  - 2022
AB  - Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood estimation was used to conduct a coordinate-based meta-analysis of gray matter volume (GMV) alterations associated with ELAs, including sub-analyses for different age groups and maltreatment as specific ELA-type. The analyses uncovered a convergence of pooled ELA-effects on GMV in the right hippocampus and amygdala and the left inferior frontal gyrus, age-specific effects for the right amygdala and hippocampus in children and adolescents, and maltreatment-specific effects for the right perigenual anterior cingulate cortex in adults. These results reveal a possible underlying commonality in the impact of adversity and also point to specific age and maltreatment effects. They suggest neural markers of ELAs in regions involved in socio-emotional functioning and stress regulation, with the potential to be used as targets for interventions designed to buffer or reverse harmful ELA-effects.
LB  - PUB:(DE-HGF)16
C6  - pmid:35189164
UR  - <Go to ISI:>//WOS:000819835100003
DO  - DOI:10.1016/j.neubiorev.2022.104589
UR  - https://juser.fz-juelich.de/record/906475
ER  -