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| 001 | 906475 | ||
| 005 | 20230123110602.0 | ||
| 024 | 7 | _ | |a 10.1016/j.neubiorev.2022.104589 |2 doi |
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| 100 | 1 | _ | |a Pollok, Tania M. |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2022 |b Elsevier Science |
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| 520 | _ | _ | |a Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood estimation was used to conduct a coordinate-based meta-analysis of gray matter volume (GMV) alterations associated with ELAs, including sub-analyses for different age groups and maltreatment as specific ELA-type. The analyses uncovered a convergence of pooled ELA-effects on GMV in the right hippocampus and amygdala and the left inferior frontal gyrus, age-specific effects for the right amygdala and hippocampus in children and adolescents, and maltreatment-specific effects for the right perigenual anterior cingulate cortex in adults. These results reveal a possible underlying commonality in the impact of adversity and also point to specific age and maltreatment effects. They suggest neural markers of ELAs in regions involved in socio-emotional functioning and stress regulation, with the potential to be used as targets for interventions designed to buffer or reverse harmful ELA-effects. |
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| 700 | 1 | _ | |a Kaiser, Anna |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Kraaijenvanger, Eline J. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Monninger, Maximilian |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Brandeis, Daniel |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Banaschewski, Tobias |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Eickhoff, Simon B. |0 P:(DE-Juel1)131678 |b 6 |
| 700 | 1 | _ | |a Holz, Nathalie E. |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.neubiorev.2022.104589 |g Vol. 135, p. 104589 - |0 PERI:(DE-600)1498433-7 |p 104589 |t Neuroscience & biobehavioral reviews |v 135 |y 2022 |x 0149-7634 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/906475/files/Pollok_et_al_Manuscript_Neurostructural_traces_ELAs_2022.pdf |y Published on 2022-02-18. Available in OpenAccess from 2023-08-18. |
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