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000906478 1001_ $$0P:(DE-Juel1)178767$$aMaleki Balajoo, Somayeh$$b0
000906478 245__ $$aDecoupling of regional neural activity and inter-regional functional connectivity in Alzheimer’s disease: a simultaneous PET/MR study
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000906478 520__ $$aPurpose: Alzheimer's disease (AD) and mild cognitive impairment (MCI) are characterized by both aberrant regional neural activity and disrupted inter-regional functional connectivity (FC). However, the effect of AD/MCI on the coupling between regional neural activity (measured by regional fluorodeoxyglucose imaging (rFDG)) and inter-regional FC (measured by resting-state functional magnetic resonance imaging (rs-fMRI)) is poorly understood.Methods: We scanned 19 patients with MCI, 33 patients with AD, and 26 healthy individuals by simultaneous FDG-PET/rs-fMRI and assessed rFDG and inter-regional FC metrics (i.e., clustering coefficient and degree centrality). Next, we examined the potential moderating effect of disease status (MCI or AD) on the link between rFDG and inter-regional FC metrics using hierarchical moderated multiple regression analysis. We also tested this effect by considering interaction between disease status and inter-regional FC metrics, as well as interaction between disease status and rFDG.Results: Our findings revealed that both rFDG and inter-regional FC metrics were disrupted in MCI and AD. Moreover, AD altered the relationship between rFDG and inter-regional FC metrics. In particular, we found that AD moderated the effect of inter-regional FC metrics of the caudate, parahippocampal gyrus, angular gyrus, supramarginal gyrus, frontal pole, inferior temporal gyrus, middle frontal, lateral occipital, supramarginal gyrus, precuneus, and thalamus on predicting their rFDG. On the other hand, AD moderated the effect of rFDG of the parietal operculum on predicting its inter-regional FC metric.
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000906478 7001_ $$aRahmani, Farzaneh$$b1
000906478 7001_ $$aKhosrowabadi, Reza$$b2
000906478 7001_ $$aMeng, Chun$$b3
000906478 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b4
000906478 7001_ $$aGrimmer, Timo$$b5
000906478 7001_ $$aZarei, Mojtaba$$b6
000906478 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b7
000906478 7001_ $$aSorg, Christian$$b8
000906478 7001_ $$0P:(DE-Juel1)188400$$aTahmasian, Masoud$$b9$$eCorresponding author
000906478 773__ $$0PERI:(DE-600)2098375-X$$a10.1007/s00259-022-05692-1$$n9$$p3173–3185$$tEuropean journal of nuclear medicine and molecular imaging$$v49$$x0340-6997$$y2022
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