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@ARTICLE{MalekiBalajoo:906478,
      author       = {Maleki Balajoo, Somayeh and Rahmani, Farzaneh and
                      Khosrowabadi, Reza and Meng, Chun and Eickhoff, Simon B. and
                      Grimmer, Timo and Zarei, Mojtaba and Drzezga, Alexander and
                      Sorg, Christian and Tahmasian, Masoud},
      title        = {{D}ecoupling of regional neural activity and inter-regional
                      functional connectivity in {A}lzheimer’s disease: a
                      simultaneous {PET}/{MR} study},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {49},
      number       = {9},
      issn         = {0340-6997},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2022-01481},
      pages        = {3173–3185},
      year         = {2022},
      abstract     = {Purpose: Alzheimer's disease (AD) and mild cognitive
                      impairment (MCI) are characterized by both aberrant regional
                      neural activity and disrupted inter-regional functional
                      connectivity (FC). However, the effect of AD/MCI on the
                      coupling between regional neural activity (measured by
                      regional fluorodeoxyglucose imaging (rFDG)) and
                      inter-regional FC (measured by resting-state functional
                      magnetic resonance imaging (rs-fMRI)) is poorly
                      understood.Methods: We scanned 19 patients with MCI, 33
                      patients with AD, and 26 healthy individuals by simultaneous
                      FDG-PET/rs-fMRI and assessed rFDG and inter-regional FC
                      metrics (i.e., clustering coefficient and degree
                      centrality). Next, we examined the potential moderating
                      effect of disease status (MCI or AD) on the link between
                      rFDG and inter-regional FC metrics using hierarchical
                      moderated multiple regression analysis. We also tested this
                      effect by considering interaction between disease status and
                      inter-regional FC metrics, as well as interaction between
                      disease status and rFDG.Results: Our findings revealed that
                      both rFDG and inter-regional FC metrics were disrupted in
                      MCI and AD. Moreover, AD altered the relationship between
                      rFDG and inter-regional FC metrics. In particular, we found
                      that AD moderated the effect of inter-regional FC metrics of
                      the caudate, parahippocampal gyrus, angular gyrus,
                      supramarginal gyrus, frontal pole, inferior temporal gyrus,
                      middle frontal, lateral occipital, supramarginal gyrus,
                      precuneus, and thalamus on predicting their rFDG. On the
                      other hand, AD moderated the effect of rFDG of the parietal
                      operculum on predicting its inter-regional FC metric.},
      cin          = {INM-7 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35199225},
      UT           = {WOS:000760059600001},
      doi          = {10.1007/s00259-022-05692-1},
      url          = {https://juser.fz-juelich.de/record/906478},
}