000906544 001__ 906544
000906544 005__ 20231213202048.0
000906544 0247_ $$2doi$$a10.1089/neu.2021.0017
000906544 0247_ $$2ISSN$$a0737-5999
000906544 0247_ $$2ISSN$$a0897-7151
000906544 0247_ $$2ISSN$$a1557-9042
000906544 0247_ $$2Handle$$a2128/30889
000906544 0247_ $$2pmid$$a33906419
000906544 0247_ $$2WOS$$aWOS:000656636800001
000906544 037__ $$aFZJ-2022-01508
000906544 082__ $$a610
000906544 1001_ $$0P:(DE-HGF)0$$aJia, Xiaoyan$$b0
000906544 245__ $$aA Longitudinal Study of White Matter Functional Network in Mild Traumatic Brain Injury
000906544 260__ $$aLarchmont, NY$$bLiebert$$c2021
000906544 3367_ $$2DRIVER$$aarticle
000906544 3367_ $$2DataCite$$aOutput Types/Journal article
000906544 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1702453274_10687
000906544 3367_ $$2BibTeX$$aARTICLE
000906544 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000906544 3367_ $$00$$2EndNote$$aJournal Article
000906544 520__ $$aSome patients after mild traumatic brain injury (mTBI) experience microstructural damages in the long-distance white matter (WM) connections, which disrupts the functional connectome of large-scale brain networks that support cognitive function. Patterns of WM structural damage following mTBI were well documented using diffusion tensor imaging (DTI). However, the functional organization of WM and its association with gray matter functional networks (GM-FNs) and its DTI metrics remain unknown. The present study adopted resting-state functional magnetic resonance imaging to explore WM functional properties in mTBI patients (108 acute patients, 48 chronic patients, 46 healthy controls [HCs]). Eleven large-scale WM functional networks (WM-FNs) were constructed by the k-means clustering algorithm of voxel-wise WM functional connectivity (FC). Compared with HCs, acute mTBI patients observed enhanced FC between inferior fronto-occipital fasciculus (IFOF) WM-FN and primary sensorimotor WM-FNs, and cortical primary sensorimotor GM-FNs. Further, acute mTBI patients showed increased DTI metrics (mean diffusivity, axial diffusivity, and radial diffusivity) in deep WM-FNs and higher-order cognitive WM-FNs. Moreover, mTBI patients demonstrated full recovery of FC and partial recovery of DTI metrics in the chronic stage. Additionally, enhanced FC between IFOF WM-FN and anterior cerebellar GM-FN was correlated with impaired information processing speed. Our findings provide novel evidence for functional and structural alteration of WM-FNs in mTBI patients. Importantly, the convergent damage of the IFOF network might imply its crucial role in our understanding of the pathophysiology mechanism of mTBI patients.
000906544 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000906544 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000906544 7001_ $$0P:(DE-HGF)0$$aChang, Xuebin$$b1
000906544 7001_ $$0P:(DE-HGF)0$$aBai, Lijun$$b2
000906544 7001_ $$0P:(DE-HGF)0$$aWang, Yulin$$b3
000906544 7001_ $$0P:(DE-Juel1)190904$$aDong, Debo$$b4
000906544 7001_ $$0P:(DE-HGF)0$$aGan, Shuoqiu$$b5
000906544 7001_ $$0P:(DE-HGF)0$$aWang, Shan$$b6
000906544 7001_ $$0P:(DE-HGF)0$$aLi, Xuan$$b7
000906544 7001_ $$0P:(DE-HGF)0$$aYang, Xuefei$$b8
000906544 7001_ $$0P:(DE-HGF)0$$aSun, Yinxiang$$b9
000906544 7001_ $$0P:(DE-HGF)0$$aLi, Tianhui$$b10
000906544 7001_ $$0P:(DE-HGF)0$$aXiong, Feng$$b11
000906544 7001_ $$0P:(DE-HGF)0$$aNiu, Xuan$$b12
000906544 7001_ $$0P:(DE-HGF)0$$aYan, Hao$$b13$$eCorresponding author
000906544 773__ $$0PERI:(DE-600)2030888-7$$a10.1089/neu.2021.0017$$gVol. 38, no. 19, p. 2686 - 2697$$n19$$p2686 - 2697$$tJournal of neurotrauma$$v38$$x0737-5999$$y2021
000906544 8564_ $$uhttps://juser.fz-juelich.de/record/906544/files/2020.09.25.313338v1.full.pdf$$yOpenAccess
000906544 8564_ $$uhttps://juser.fz-juelich.de/record/906544/files/A%20longitudinal%20study%20of%20white%20matter%20functional%20network%20in%20mild%20traumatic%20brain%20injury.pdf$$yOpenAccess
000906544 909CO $$ooai:juser.fz-juelich.de:906544$$popenaire$$pdnbdelivery$$popen_access$$pVDB$$pdriver
000906544 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)190904$$aForschungszentrum Jülich$$b4$$kFZJ
000906544 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000906544 9141_ $$y2022
000906544 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2021-01-30
000906544 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000906544 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NEUROTRAUM : 2019$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000906544 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2021-01-30
000906544 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2021-01-30$$wger
000906544 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-01-30
000906544 920__ $$lyes
000906544 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000906544 980__ $$ajournal
000906544 980__ $$aVDB
000906544 980__ $$aI:(DE-Juel1)INM-7-20090406
000906544 980__ $$aUNRESTRICTED
000906544 9801_ $$aFullTexts