TY  - JOUR
AU  - Jia, Xiaoyan
AU  - Chang, Xuebin
AU  - Bai, Lijun
AU  - Wang, Yulin
AU  - Dong, Debo
AU  - Gan, Shuoqiu
AU  - Wang, Shan
AU  - Li, Xuan
AU  - Yang, Xuefei
AU  - Sun, Yinxiang
AU  - Li, Tianhui
AU  - Xiong, Feng
AU  - Niu, Xuan
AU  - Yan, Hao
TI  - A Longitudinal Study of White Matter Functional Network in Mild Traumatic Brain Injury
JO  - Journal of neurotrauma
VL  - 38
IS  - 19
SN  - 0737-5999
CY  - Larchmont, NY
PB  - Liebert
M1  - FZJ-2022-01508
SP  - 2686 - 2697
PY  - 2021
AB  - Some patients after mild traumatic brain injury (mTBI) experience microstructural damages in the long-distance white matter (WM) connections, which disrupts the functional connectome of large-scale brain networks that support cognitive function. Patterns of WM structural damage following mTBI were well documented using diffusion tensor imaging (DTI). However, the functional organization of WM and its association with gray matter functional networks (GM-FNs) and its DTI metrics remain unknown. The present study adopted resting-state functional magnetic resonance imaging to explore WM functional properties in mTBI patients (108 acute patients, 48 chronic patients, 46 healthy controls [HCs]). Eleven large-scale WM functional networks (WM-FNs) were constructed by the k-means clustering algorithm of voxel-wise WM functional connectivity (FC). Compared with HCs, acute mTBI patients observed enhanced FC between inferior fronto-occipital fasciculus (IFOF) WM-FN and primary sensorimotor WM-FNs, and cortical primary sensorimotor GM-FNs. Further, acute mTBI patients showed increased DTI metrics (mean diffusivity, axial diffusivity, and radial diffusivity) in deep WM-FNs and higher-order cognitive WM-FNs. Moreover, mTBI patients demonstrated full recovery of FC and partial recovery of DTI metrics in the chronic stage. Additionally, enhanced FC between IFOF WM-FN and anterior cerebellar GM-FN was correlated with impaired information processing speed. Our findings provide novel evidence for functional and structural alteration of WM-FNs in mTBI patients. Importantly, the convergent damage of the IFOF network might imply its crucial role in our understanding of the pathophysiology mechanism of mTBI patients.
LB  - PUB:(DE-HGF)16
C6  - 33906419
UR  - <Go to ISI:>//WOS:000656636800001
DO  - DOI:10.1089/neu.2021.0017
UR  - https://juser.fz-juelich.de/record/906544
ER  -