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@ARTICLE{Jia:906544,
      author       = {Jia, Xiaoyan and Chang, Xuebin and Bai, Lijun and Wang,
                      Yulin and Dong, Debo and Gan, Shuoqiu and Wang, Shan and Li,
                      Xuan and Yang, Xuefei and Sun, Yinxiang and Li, Tianhui and
                      Xiong, Feng and Niu, Xuan and Yan, Hao},
      title        = {{A} {L}ongitudinal {S}tudy of {W}hite {M}atter {F}unctional
                      {N}etwork in {M}ild {T}raumatic {B}rain {I}njury},
      journal      = {Journal of neurotrauma},
      volume       = {38},
      number       = {19},
      issn         = {0737-5999},
      address      = {Larchmont, NY},
      publisher    = {Liebert},
      reportid     = {FZJ-2022-01508},
      pages        = {2686 - 2697},
      year         = {2021},
      abstract     = {Some patients after mild traumatic brain injury (mTBI)
                      experience microstructural damages in the long-distance
                      white matter (WM) connections, which disrupts the functional
                      connectome of large-scale brain networks that support
                      cognitive function. Patterns of WM structural damage
                      following mTBI were well documented using diffusion tensor
                      imaging (DTI). However, the functional organization of WM
                      and its association with gray matter functional networks
                      (GM-FNs) and its DTI metrics remain unknown. The present
                      study adopted resting-state functional magnetic resonance
                      imaging to explore WM functional properties in mTBI patients
                      (108 acute patients, 48 chronic patients, 46 healthy
                      controls [HCs]). Eleven large-scale WM functional networks
                      (WM-FNs) were constructed by the k-means clustering
                      algorithm of voxel-wise WM functional connectivity (FC).
                      Compared with HCs, acute mTBI patients observed enhanced FC
                      between inferior fronto-occipital fasciculus (IFOF) WM-FN
                      and primary sensorimotor WM-FNs, and cortical primary
                      sensorimotor GM-FNs. Further, acute mTBI patients showed
                      increased DTI metrics (mean diffusivity, axial diffusivity,
                      and radial diffusivity) in deep WM-FNs and higher-order
                      cognitive WM-FNs. Moreover, mTBI patients demonstrated full
                      recovery of FC and partial recovery of DTI metrics in the
                      chronic stage. Additionally, enhanced FC between IFOF WM-FN
                      and anterior cerebellar GM-FN was correlated with impaired
                      information processing speed. Our findings provide novel
                      evidence for functional and structural alteration of WM-FNs
                      in mTBI patients. Importantly, the convergent damage of the
                      IFOF network might imply its crucial role in our
                      understanding of the pathophysiology mechanism of mTBI
                      patients.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33906419},
      UT           = {WOS:000656636800001},
      doi          = {10.1089/neu.2021.0017},
      url          = {https://juser.fz-juelich.de/record/906544},
}