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000906550 245__ $$aInfluence of Chain Length of Gradient and Block Copoly(2‐oxazoline)s on Self‐Assembly and Drug Encapsulation
000906550 260__ $$aWeinheim$$bWiley-VCH$$c2022
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000906550 520__ $$aAmphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock copolymer micelles. Size, morphology, and stability of self-assembled nanoparticles, loading of hydrophobic drug curcumin, as well as cytotoxicities of the prepared nanoformulations are examined using copoly(2-oxazoline)s with varying chain lengths and comonomer ratios. In addition to several interesting differences between the two copolymer architecture classes, such as more compact self-assembled structures with faster exchange dynamics for the gradient copolymers, it is concluded that gradient copolymers provide stable curcumin nanoformulations with comparable drug loadings to block copolymer systems and benefit from more straightforward copolymer synthesis. The study demonstrates the potential of amphiphilic gradient copolymers as a versatile platform for the synthesis of new polymer therapeutics.
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000906550 65017 $$0V:(DE-MLZ)GC-1602-2016$$2V:(DE-HGF)$$aPolymers, Soft Nano Particles and  Proteins$$x0
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000906550 7001_ $$0P:(DE-HGF)0$$aBardoula, Valentin$$b1
000906550 7001_ $$0P:(DE-HGF)0$$aVuorimaa-Laukkanen, Elina$$b2
000906550 7001_ $$0P:(DE-HGF)0$$aGedda, Lars$$b3
000906550 7001_ $$0P:(DE-HGF)0$$aEdwards, Katarina$$b4
000906550 7001_ $$0P:(DE-Juel1)130905$$aRadulescu, Aurel$$b5
000906550 7001_ $$0P:(DE-HGF)0$$aMun, Grigoriy A.$$b6
000906550 7001_ $$0P:(DE-HGF)0$$aGuo, Yong$$b7
000906550 7001_ $$0P:(DE-HGF)0$$aZhou, Junnian$$b8
000906550 7001_ $$0P:(DE-HGF)0$$aZhang, Hongbo$$b9
000906550 7001_ $$0P:(DE-HGF)0$$aNardello-Rataj, Véronique$$b10
000906550 7001_ $$0P:(DE-HGF)0$$aFilippov, Sergey$$b11
000906550 7001_ $$00000-0001-7398-2058$$aHoogenboom, Richard$$b12$$eCorresponding author
000906550 773__ $$0PERI:(DE-600)2168935-0$$a10.1002/smll.202106251$$gp. 2106251 -$$n17$$p2106251$$tSmall$$v18$$x1613-6810$$y2022
000906550 8564_ $$uhttps://juser.fz-juelich.de/record/906550/files/Small%20-%202022%20-%20Sedlacek%20-%20Influence%20of%20Chain%20Length%20of%20Gradient%20and%20Block%20Copoly%202%E2%80%90oxazoline%20s%20on%20Self%E2%80%90Assembly%20and%20Drug.pdf
000906550 8564_ $$uhttps://juser.fz-juelich.de/record/906550/files/Small_Gradients_PMeOx_PPhOx_final.pdf$$yPublished on 2022-02-25. Available in OpenAccess from 2023-02-25.
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