TY  - JOUR
AU  - Sedlacek, Ondrej
AU  - Bardoula, Valentin
AU  - Vuorimaa-Laukkanen, Elina
AU  - Gedda, Lars
AU  - Edwards, Katarina
AU  - Radulescu, Aurel
AU  - Mun, Grigoriy A.
AU  - Guo, Yong
AU  - Zhou, Junnian
AU  - Zhang, Hongbo
AU  - Nardello-Rataj, Véronique
AU  - Filippov, Sergey
AU  - Hoogenboom, Richard
TI  - Influence of Chain Length of Gradient and Block Copoly(2‐oxazoline)s on Self‐Assembly and Drug Encapsulation
JO  - Small
VL  - 18
IS  - 17
SN  - 1613-6810
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2022-01511
SP  - 2106251
PY  - 2022
AB  - Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock copolymer micelles. Size, morphology, and stability of self-assembled nanoparticles, loading of hydrophobic drug curcumin, as well as cytotoxicities of the prepared nanoformulations are examined using copoly(2-oxazoline)s with varying chain lengths and comonomer ratios. In addition to several interesting differences between the two copolymer architecture classes, such as more compact self-assembled structures with faster exchange dynamics for the gradient copolymers, it is concluded that gradient copolymers provide stable curcumin nanoformulations with comparable drug loadings to block copolymer systems and benefit from more straightforward copolymer synthesis. The study demonstrates the potential of amphiphilic gradient copolymers as a versatile platform for the synthesis of new polymer therapeutics.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000760883400001
DO  - DOI:10.1002/smll.202106251
UR  - https://juser.fz-juelich.de/record/906550
ER  -