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@ARTICLE{Sedlacek:906550,
      author       = {Sedlacek, Ondrej and Bardoula, Valentin and
                      Vuorimaa-Laukkanen, Elina and Gedda, Lars and Edwards,
                      Katarina and Radulescu, Aurel and Mun, Grigoriy A. and Guo,
                      Yong and Zhou, Junnian and Zhang, Hongbo and Nardello-Rataj,
                      Véronique and Filippov, Sergey and Hoogenboom, Richard},
      title        = {{I}nfluence of {C}hain {L}ength of {G}radient and {B}lock
                      {C}opoly(2‐oxazoline)s on {S}elf‐{A}ssembly and {D}rug
                      {E}ncapsulation},
      journal      = {Small},
      volume       = {18},
      number       = {17},
      issn         = {1613-6810},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2022-01511},
      pages        = {2106251},
      year         = {2022},
      abstract     = {Amphiphilic gradient copolymers represent a promising
                      alternative to extensively used block copolymers due to
                      their facile one-step synthesis by statistical
                      copolymerization of monomers of different reactivity.
                      Herein, an in-depth analysis is provided of micelles based
                      on amphiphilic gradient poly(2-oxazoline)s with different
                      chain lengths to evaluate their potential for micellar drug
                      delivery systems and compare them to the analogous diblock
                      copolymer micelles. Size, morphology, and stability of
                      self-assembled nanoparticles, loading of hydrophobic drug
                      curcumin, as well as cytotoxicities of the prepared
                      nanoformulations are examined using copoly(2-oxazoline)s
                      with varying chain lengths and comonomer ratios. In addition
                      to several interesting differences between the two copolymer
                      architecture classes, such as more compact self-assembled
                      structures with faster exchange dynamics for the gradient
                      copolymers, it is concluded that gradient copolymers provide
                      stable curcumin nanoformulations with comparable drug
                      loadings to block copolymer systems and benefit from more
                      straightforward copolymer synthesis. The study demonstrates
                      the potential of amphiphilic gradient copolymers as a
                      versatile platform for the synthesis of new polymer
                      therapeutics.},
      cin          = {JCNS-FRM-II / MLZ / JCNS-1 / JCNS-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)JCNS-4-20201012},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4) / 632 - Materials – Quantum, Complex and
                      Functional Materials (POF4-632)},
      pid          = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000760883400001},
      doi          = {10.1002/smll.202106251},
      url          = {https://juser.fz-juelich.de/record/906550},
}