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@ARTICLE{Cheung:906738,
      author       = {Cheung, Giselle and Bataveljic, Danijela and Visser, Josien
                      and Kumar, Naresh and Moulard, Julien and Dallérac, Glenn
                      and Mozheiko, Daria and Rollenhagen, Astrid and Ezan, Pascal
                      and Mongin, Cédric and Chever, Oana and Bemelmans,
                      Alexis-Pierre and Lübke, Joachim and Leray, Isabelle and
                      Rouach, Nathalie},
      title        = {{P}hysiological synaptic activity and recognition memory
                      require astroglial glutamine},
      journal      = {Nature Communications},
      volume       = {13},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2022-01660},
      pages        = {753},
      year         = {2022},
      abstract     = {Presynaptic glutamate replenishment is fundamental to brain
                      function. In high activity regimes, such as epileptic
                      episodes, this process is thought to rely on the
                      glutamate-glutamine cycle between neurons and astrocytes.
                      However the presence of an astroglial glutamine supply, as
                      well as its functional relevance in vivo in the healthy
                      brain remain controversial, partly due to a lack of tools
                      that can directly examine glutamine transfer. Here, we
                      generated a fluorescent probe that tracks glutamine in live
                      cells, which provides direct visual evidence of an
                      activity-dependent glutamine supply from astroglial networks
                      to presynaptic structures under physiological conditions.
                      This mobilization is mediated by connexin43, an astroglial
                      protein with both gap-junction and hemichannel functions,
                      and is essential for synaptic transmission and object
                      recognition memory. Our findings uncover an indispensable
                      recruitment of astroglial glutamine in physiological
                      synaptic activity and memory via an unconventional pathway,
                      thus providing an astrocyte basis for cognitive processes.},
      cin          = {INM-10},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-10-20170113},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / AstroWireSyn - Wiring synaptic circuits with
                      astroglial connexins: mechanisms, dynamics and impact for
                      critical period plasticity (683154) / EU-GliaPhD - Training,
                      Research and Raising of Public Awareness in Cell Biology and
                      Pathology of Neuroglia (722053) / ASTRORIPPLES - Functional
                      roles of astroglial connexins in the generation of sharp
                      wave ripples (622289)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)683154 /
                      G:(EU-Grant)722053 / G:(EU-Grant)622289},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35136061},
      UT           = {WOS:000757297200017},
      doi          = {10.1038/s41467-022-28331-7},
      url          = {https://juser.fz-juelich.de/record/906738},
}