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@ARTICLE{Spring:906757,
      author       = {Spöring, Jan-Dirk and Graf von Westarp, William and Kipp,
                      Carina Ronja and Jupke, Andreas and Rother, Dörte},
      title        = {{E}nzymatic {C}ascade in a {S}imultaneous, {O}ne-{P}ot
                      {A}pproach with {I}n {S}itu {P}roduct {S}eparation for the
                      {A}symmetric {P}roduction of (4 {S} ,5 {S} )-{O}ctanediol},
      journal      = {Organic process research $\&$ development},
      volume       = {26},
      number       = {7},
      issn         = {1083-6160},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {FZJ-2022-01672},
      pages        = {2038–2045},
      year         = {2022},
      abstract     = {Stereopure aliphatic diols are an interesting class of
                      compounds because of their potential applications as
                      precursors for chemical catalysts, for high-value polymers,
                      or as precursors for cyclic acetals. We present a
                      simultaneous enzymatic two-step, one-pot cascade for the
                      synthesis of vicinal diols with excellent de and ee values
                      with the exemplary reaction system from butanal to
                      (4S,5S)-octanediol. This reaction is restricted by an
                      unfavorable reaction equilibrium. For an intensification of
                      the reaction toward higher conversions in equilibrium and
                      increased space time yields (STY), aqueous, microaqueous,
                      and biphasic reaction systems for in situ product removal
                      (ISPR) were experimentally investigated and compared.
                      Process concepts for the purification of (4S,5S)-octanediol
                      from each reaction system were developed and assessed in
                      terms of product-specific energy demand. The two-phase
                      reaction system for in situ product removal is favorable for
                      the enzymatic reactions in terms of yield and STY at
                      different time points. In comparison to the aqueous and
                      microaqueous reaction systems, the specific energy demand
                      for (4S,5S)-octanediol recovery is drastically reduced by
                      approximately a factor of seven when performing ISPR using a
                      biphasic system in comparison to an aqueous reaction
                      system.},
      cin          = {IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217) / DFG
                      project 491111487 - Open-Access-Publikationskosten / 2022 -
                      2024 / Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-2172 / G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000823740000001},
      doi          = {10.1021/acs.oprd.1c00433},
      url          = {https://juser.fz-juelich.de/record/906757},
}