000906803 001__ 906803
000906803 005__ 20230123110607.0
000906803 0247_ $$2doi$$a10.1038/s41380-022-01489-8
000906803 0247_ $$2ISSN$$a1359-4184
000906803 0247_ $$2ISSN$$a1476-5578
000906803 0247_ $$2Handle$$a2128/31462
000906803 0247_ $$2altmetric$$aaltmetric:124336898
000906803 0247_ $$2pmid$$apmid:35264730
000906803 0247_ $$2WOS$$aWOS:000766422100003
000906803 037__ $$aFZJ-2022-01701
000906803 082__ $$a610
000906803 1001_ $$0P:(DE-Juel1)173866$$aWang, Yaping$$b0$$ufzj
000906803 245__ $$aUncovering the genetic profiles underlying the intrinsic organization of the human cerebellum
000906803 260__ $$aLondon$$bMacmillan$$c2022
000906803 3367_ $$2DRIVER$$aarticle
000906803 3367_ $$2DataCite$$aOutput Types/Journal article
000906803 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1657289411_27127
000906803 3367_ $$2BibTeX$$aARTICLE
000906803 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000906803 3367_ $$00$$2EndNote$$aJournal Article
000906803 520__ $$aThe functional diversity of the human cerebellum is largely believed to be derived more from its extensive connections rather than being limited to its mostly invariant architecture. However, whether and how the determination of cerebellar connections in its intrinsic organization interact with microscale gene expression is still unknown. Here we decode the genetic profiles of the cerebellar functional organization by investigating the genetic substrates simultaneously linking cerebellar functional heterogeneity and its drivers, i.e., the connections. We not only identified 443 network-specific genes but also discovered that their co-expression pattern correlated strongly with intra-cerebellar functional connectivity (FC). Ninety of these genes were also linked to the FC of cortico-cerebellar cognitive-limbic networks. To further discover the biological functions of these genes, we performed a "virtual gene knock-out" by observing the change in the coupling between gene co-expression and FC and divided the genes into two subsets, i.e., a positive gene contribution indicator (GCI+) involved in cerebellar neurodevelopment and a negative gene set (GCI-) related to neurotransmission. A more interesting finding is that GCI- is significantly linked with the cerebellar connectivity-behavior association and many recognized brain diseases that are closely linked with the cerebellar functional abnormalities. Our results could collectively help to rethink the genetic substrates underlying the cerebellar functional organization and offer possible micro-macro interacted mechanistic interpretations of the cerebellum-involved high order functions and dysfunctions in neuropsychiatric disorders.
000906803 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000906803 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000906803 7001_ $$0P:(DE-HGF)0$$aChai, Lin$$b1
000906803 7001_ $$0P:(DE-Juel1)180306$$aChu, Congying$$b2$$eCorresponding author
000906803 7001_ $$0P:(DE-HGF)0$$aLi, Deying$$b3
000906803 7001_ $$0P:(DE-HGF)0$$aGao, Chaohong$$b4
000906803 7001_ $$0P:(DE-Juel1)168420$$aWu, Xia$$b5
000906803 7001_ $$0P:(DE-HGF)0$$aYang, Zhengyi$$b6
000906803 7001_ $$0P:(DE-HGF)0$$aZhang, Yu$$b7
000906803 7001_ $$0P:(DE-HGF)0$$aXu, Junhai$$b8
000906803 7001_ $$0P:(DE-HGF)0$$aNyengaard, Jens Randel$$b9
000906803 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b10
000906803 7001_ $$0P:(DE-Juel1)184736$$aLiu, Bing$$b11
000906803 7001_ $$00000-0001-8606-7641$$aMadsen, Kristoffer Hougaard$$b12
000906803 7001_ $$00000-0002-0607-3775$$aJiang, Tianzi$$b13
000906803 7001_ $$00000-0002-4813-621X$$aFan, Lingzhong$$b14$$eCorresponding author
000906803 773__ $$0PERI:(DE-600)1502531-7$$a10.1038/s41380-022-01489-8$$p2619–2634$$tMolecular psychiatry$$v27$$x1359-4184$$y2022
000906803 8564_ $$uhttps://juser.fz-juelich.de/record/906803/files/s41380-022-01489-8.pdf
000906803 8564_ $$uhttps://juser.fz-juelich.de/record/906803/files/preprint.pdf$$yOpenAccess
000906803 909CO $$ooai:juser.fz-juelich.de:906803$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000906803 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173866$$aForschungszentrum Jülich$$b0$$kFZJ
000906803 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)180306$$aForschungszentrum Jülich$$b2$$kFZJ
000906803 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$aExternal Institute$$b7$$kExtern
000906803 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b10$$kFZJ
000906803 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000906803 9141_ $$y2022
000906803 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-28
000906803 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-28
000906803 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000906803 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-28
000906803 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000906803 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bMOL PSYCHIATR : 2021$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-19
000906803 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bMOL PSYCHIATR : 2021$$d2022-11-19
000906803 920__ $$lyes
000906803 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000906803 980__ $$ajournal
000906803 980__ $$aVDB
000906803 980__ $$aUNRESTRICTED
000906803 980__ $$aI:(DE-Juel1)INM-7-20090406
000906803 9801_ $$aFullTexts