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@ARTICLE{Wang:906803,
      author       = {Wang, Yaping and Chai, Lin and Chu, Congying and Li, Deying
                      and Gao, Chaohong and Wu, Xia and Yang, Zhengyi and Zhang,
                      Yu and Xu, Junhai and Nyengaard, Jens Randel and Eickhoff,
                      Simon B. and Liu, Bing and Madsen, Kristoffer Hougaard and
                      Jiang, Tianzi and Fan, Lingzhong},
      title        = {{U}ncovering the genetic profiles underlying the intrinsic
                      organization of the human cerebellum},
      journal      = {Molecular psychiatry},
      volume       = {27},
      issn         = {1359-4184},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {FZJ-2022-01701},
      pages        = {2619–2634},
      year         = {2022},
      abstract     = {The functional diversity of the human cerebellum is largely
                      believed to be derived more from its extensive connections
                      rather than being limited to its mostly invariant
                      architecture. However, whether and how the determination of
                      cerebellar connections in its intrinsic organization
                      interact with microscale gene expression is still unknown.
                      Here we decode the genetic profiles of the cerebellar
                      functional organization by investigating the genetic
                      substrates simultaneously linking cerebellar functional
                      heterogeneity and its drivers, i.e., the connections. We not
                      only identified 443 network-specific genes but also
                      discovered that their co-expression pattern correlated
                      strongly with intra-cerebellar functional connectivity (FC).
                      Ninety of these genes were also linked to the FC of
                      cortico-cerebellar cognitive-limbic networks. To further
                      discover the biological functions of these genes, we
                      performed a "virtual gene knock-out" by observing the change
                      in the coupling between gene co-expression and FC and
                      divided the genes into two subsets, i.e., a positive gene
                      contribution indicator (GCI+) involved in cerebellar
                      neurodevelopment and a negative gene set (GCI-) related to
                      neurotransmission. A more interesting finding is that GCI-
                      is significantly linked with the cerebellar
                      connectivity-behavior association and many recognized brain
                      diseases that are closely linked with the cerebellar
                      functional abnormalities. Our results could collectively
                      help to rethink the genetic substrates underlying the
                      cerebellar functional organization and offer possible
                      micro-macro interacted mechanistic interpretations of the
                      cerebellum-involved high order functions and dysfunctions in
                      neuropsychiatric disorders.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35264730},
      UT           = {WOS:000766422100003},
      doi          = {10.1038/s41380-022-01489-8},
      url          = {https://juser.fz-juelich.de/record/906803},
}