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@ARTICLE{Wang:906803,
author = {Wang, Yaping and Chai, Lin and Chu, Congying and Li, Deying
and Gao, Chaohong and Wu, Xia and Yang, Zhengyi and Zhang,
Yu and Xu, Junhai and Nyengaard, Jens Randel and Eickhoff,
Simon B. and Liu, Bing and Madsen, Kristoffer Hougaard and
Jiang, Tianzi and Fan, Lingzhong},
title = {{U}ncovering the genetic profiles underlying the intrinsic
organization of the human cerebellum},
journal = {Molecular psychiatry},
volume = {27},
issn = {1359-4184},
address = {London},
publisher = {Macmillan},
reportid = {FZJ-2022-01701},
pages = {2619–2634},
year = {2022},
abstract = {The functional diversity of the human cerebellum is largely
believed to be derived more from its extensive connections
rather than being limited to its mostly invariant
architecture. However, whether and how the determination of
cerebellar connections in its intrinsic organization
interact with microscale gene expression is still unknown.
Here we decode the genetic profiles of the cerebellar
functional organization by investigating the genetic
substrates simultaneously linking cerebellar functional
heterogeneity and its drivers, i.e., the connections. We not
only identified 443 network-specific genes but also
discovered that their co-expression pattern correlated
strongly with intra-cerebellar functional connectivity (FC).
Ninety of these genes were also linked to the FC of
cortico-cerebellar cognitive-limbic networks. To further
discover the biological functions of these genes, we
performed a "virtual gene knock-out" by observing the change
in the coupling between gene co-expression and FC and
divided the genes into two subsets, i.e., a positive gene
contribution indicator (GCI+) involved in cerebellar
neurodevelopment and a negative gene set (GCI-) related to
neurotransmission. A more interesting finding is that GCI-
is significantly linked with the cerebellar
connectivity-behavior association and many recognized brain
diseases that are closely linked with the cerebellar
functional abnormalities. Our results could collectively
help to rethink the genetic substrates underlying the
cerebellar functional organization and offer possible
micro-macro interacted mechanistic interpretations of the
cerebellum-involved high order functions and dysfunctions in
neuropsychiatric disorders.},
cin = {INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35264730},
UT = {WOS:000766422100003},
doi = {10.1038/s41380-022-01489-8},
url = {https://juser.fz-juelich.de/record/906803},
}