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000907199 1001_ $$0P:(DE-Juel1)174338$$aKrüger, Aileen$$b0
000907199 245__ $$aThe diversity of heme sensor systems – heme-responsive transcriptional regulation mediated by transient heme protein interactions
000907199 260__ $$aOxford$$bOxford Univ. Press$$c2022
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000907199 520__ $$aHeme is a versatile molecule that is vital for nearly all cellular life by serving as prosthetic group for various enzymes or as nutritional iron source for diverse microbial species. However, elevated levels of heme is toxic to cells. The complexity of this stimulus has shaped the evolution of diverse heme sensor systems, which are involved in heme-dependent transcriptional regulation in eukaryotes and prokaryotes. The functions of these systems are manifold—ranging from the specific control of heme detoxification or uptake systems to the global integration of heme and iron homeostasis. This review focuses on heme sensor systems, regulating heme homeostasis by transient heme protein interaction. We provide an overview of known heme-binding motifs in prokaryotic and eukaryotic transcription factors. Besides the central ligands, the surrounding amino acid environment was shown to play a pivotal role in heme binding. The diversity of heme-regulatory systems, therefore, illustrates that prediction based on pure sequence information is hardly possible and requires careful experimental validation. Comprehensive understanding of heme-regulated processes is not only important for our understanding of cellular physiology, but also provides a basis for the development of novel antibacterial drugs and metabolic engineering strategies.
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000907199 7001_ $$0P:(DE-Juel1)162363$$aKeppel, Marc$$b1
000907199 7001_ $$0P:(DE-Juel1)179232$$aSharma, Vikas$$b2
000907199 7001_ $$0P:(DE-Juel1)138503$$aFrunzke, Julia$$b3$$eCorresponding author
000907199 773__ $$0PERI:(DE-600)1500468-5$$a10.1093/femsre/fuac002$$gp. fuac002$$n3$$pfuac002$$tFEMS microbiology reviews$$v45$$x0168-6445$$y2022
000907199 8564_ $$uhttps://juser.fz-juelich.de/record/907199/files/2022_Kr%C3%BCger_Review_HemeSensorSystems_preprint.pdf$$yPublished on 2022-01-13. Available in OpenAccess from 2023-01-13.$$zStatID:(DE-HGF)0510
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