TY  - JOUR
AU  - Krüger, Aileen
AU  - Keppel, Marc
AU  - Sharma, Vikas
AU  - Frunzke, Julia
TI  - The diversity of heme sensor systems – heme-responsive transcriptional regulation mediated by transient heme protein interactions
JO  - FEMS microbiology reviews
VL  - 45
IS  - 3
SN  - 0168-6445
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2022-01887
SP  - fuac002
PY  - 2022
N1  - Biotechnologie 1
AB  - Heme is a versatile molecule that is vital for nearly all cellular life by serving as prosthetic group for various enzymes or as nutritional iron source for diverse microbial species. However, elevated levels of heme is toxic to cells. The complexity of this stimulus has shaped the evolution of diverse heme sensor systems, which are involved in heme-dependent transcriptional regulation in eukaryotes and prokaryotes. The functions of these systems are manifold—ranging from the specific control of heme detoxification or uptake systems to the global integration of heme and iron homeostasis. This review focuses on heme sensor systems, regulating heme homeostasis by transient heme protein interaction. We provide an overview of known heme-binding motifs in prokaryotic and eukaryotic transcription factors. Besides the central ligands, the surrounding amino acid environment was shown to play a pivotal role in heme binding. The diversity of heme-regulatory systems, therefore, illustrates that prediction based on pure sequence information is hardly possible and requires careful experimental validation. Comprehensive understanding of heme-regulated processes is not only important for our understanding of cellular physiology, but also provides a basis for the development of novel antibacterial drugs and metabolic engineering strategies.
LB  - PUB:(DE-HGF)16
C6  - pmid:35026033
UR  - <Go to ISI:>//WOS:000758390400001
DO  - DOI:10.1093/femsre/fuac002
UR  - https://juser.fz-juelich.de/record/907199
ER  -