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@ARTICLE{Krger:907199,
      author       = {Krüger, Aileen and Keppel, Marc and Sharma, Vikas and
                      Frunzke, Julia},
      title        = {{T}he diversity of heme sensor systems – heme-responsive
                      transcriptional regulation mediated by transient heme
                      protein interactions},
      journal      = {FEMS microbiology reviews},
      volume       = {45},
      number       = {3},
      issn         = {0168-6445},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2022-01887},
      pages        = {fuac002},
      year         = {2022},
      note         = {Biotechnologie 1},
      abstract     = {Heme is a versatile molecule that is vital for nearly all
                      cellular life by serving as prosthetic group for various
                      enzymes or as nutritional iron source for diverse microbial
                      species. However, elevated levels of heme is toxic to cells.
                      The complexity of this stimulus has shaped the evolution of
                      diverse heme sensor systems, which are involved in
                      heme-dependent transcriptional regulation in eukaryotes and
                      prokaryotes. The functions of these systems are
                      manifold—ranging from the specific control of heme
                      detoxification or uptake systems to the global integration
                      of heme and iron homeostasis. This review focuses on heme
                      sensor systems, regulating heme homeostasis by transient
                      heme protein interaction. We provide an overview of known
                      heme-binding motifs in prokaryotic and eukaryotic
                      transcription factors. Besides the central ligands, the
                      surrounding amino acid environment was shown to play a
                      pivotal role in heme binding. The diversity of
                      heme-regulatory systems, therefore, illustrates that
                      prediction based on pure sequence information is hardly
                      possible and requires careful experimental validation.
                      Comprehensive understanding of heme-regulated processes is
                      not only important for our understanding of cellular
                      physiology, but also provides a basis for the development of
                      novel antibacterial drugs and metabolic engineering
                      strategies.},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35026033},
      UT           = {WOS:000758390400001},
      doi          = {10.1093/femsre/fuac002},
      url          = {https://juser.fz-juelich.de/record/907199},
}