%0 Journal Article
%A Pieperhoff, Peter
%A Südmeyer, Martin
%A Dinkelbach, Lars
%A Hartmann, Christian J.
%A Ferrea, Stefano
%A Moldovan, Alexia S.
%A Minnerop, Martina
%A Diaz-Pier, Sandra
%A Schnitzler, Alfons
%A Amunts, Katrin
%T Regional changes of brain structure during progression of idiopathic Parkinson's disease – A longitudinal study using deformation based morphometry
%J Cortex
%V 151
%@ 0010-9452
%C New York, NY
%I Elsevier
%M FZJ-2022-01944
%P 188 - 210
%D 2022
%X Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD are the degeneration of dopaminergic neurons in the striatum, and the propagation of aggregates of misfolded α-synuclein in the brain following a specific pattern (Braak et al., 2006). The relationship of this pattern with motor and cognitive symptoms is still equivocal. Therefore, we investigated longitudinally the spatio-temporal patterns of atrophy propagation in PD, their inter-individual variability and associations with clinical symptoms. Magnetic resonance (MR) images of 37 PD patients and 27 controls were acquired at up to 15 time-points per subject, and over observation periods of up to 8.8 years (mean: 3.7 years). MR images were analyzed by Deformation-based Morphometry to measure region volumes and their longitudinal changes. Differences of these regional volume data between patients and controls and their associations with clinical symptoms were calculated.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35439717
%U <Go to ISI:>//WOS:000797255700003
%R 10.1016/j.cortex.2022.03.009
%U https://juser.fz-juelich.de/record/907293