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000907293 1001_ $$0P:(DE-Juel1)131666$$aPieperhoff, Peter$$b0$$eCorresponding author
000907293 245__ $$aRegional changes of brain structure during progression of idiopathic Parkinson's disease – A longitudinal study using deformation based morphometry
000907293 260__ $$aNew York, NY$$bElsevier$$c2022
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000907293 520__ $$aIdiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD are the degeneration of dopaminergic neurons in the striatum, and the propagation of aggregates of misfolded α-synuclein in the brain following a specific pattern (Braak et al., 2006). The relationship of this pattern with motor and cognitive symptoms is still equivocal. Therefore, we investigated longitudinally the spatio-temporal patterns of atrophy propagation in PD, their inter-individual variability and associations with clinical symptoms. Magnetic resonance (MR) images of 37 PD patients and 27 controls were acquired at up to 15 time-points per subject, and over observation periods of up to 8.8 years (mean: 3.7 years). MR images were analyzed by Deformation-based Morphometry to measure region volumes and their longitudinal changes. Differences of these regional volume data between patients and controls and their associations with clinical symptoms were calculated.
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000907293 7001_ $$0P:(DE-HGF)0$$aSüdmeyer, Martin$$b1
000907293 7001_ $$0P:(DE-HGF)0$$aDinkelbach, Lars$$b2
000907293 7001_ $$0P:(DE-HGF)0$$aHartmann, Christian J.$$b3
000907293 7001_ $$0P:(DE-HGF)0$$aFerrea, Stefano$$b4
000907293 7001_ $$0P:(DE-HGF)0$$aMoldovan, Alexia S.$$b5
000907293 7001_ $$0P:(DE-Juel1)131622$$aMinnerop, Martina$$b6$$ufzj
000907293 7001_ $$0P:(DE-Juel1)165859$$aDiaz-Pier, Sandra$$b7
000907293 7001_ $$00000-0002-6414-7939$$aSchnitzler, Alfons$$b8
000907293 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b9$$ufzj
000907293 773__ $$0PERI:(DE-600)2080335-7$$a10.1016/j.cortex.2022.03.009$$gVol. 151, p. 188 - 210$$p188 - 210$$tCortex$$v151$$x0010-9452$$y2022
000907293 8564_ $$uhttps://juser.fz-juelich.de/record/907293/files/Invoice_OAD0000200652.pdf
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