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@ARTICLE{Pieperhoff:907293,
      author       = {Pieperhoff, Peter and Südmeyer, Martin and Dinkelbach,
                      Lars and Hartmann, Christian J. and Ferrea, Stefano and
                      Moldovan, Alexia S. and Minnerop, Martina and Diaz-Pier,
                      Sandra and Schnitzler, Alfons and Amunts, Katrin},
      title        = {{R}egional changes of brain structure during progression of
                      idiopathic {P}arkinson's disease – {A} longitudinal study
                      using deformation based morphometry},
      journal      = {Cortex},
      volume       = {151},
      issn         = {0010-9452},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {FZJ-2022-01944},
      pages        = {188 - 210},
      year         = {2022},
      abstract     = {Idiopathic Parkinson's disease (PD) is a neurodegenerative
                      disorder with a broad spectrum of motor and non-motor
                      symptoms. The neuropathological characteristics of
                      idiopathic PD are the degeneration of dopaminergic neurons
                      in the striatum, and the propagation of aggregates of
                      misfolded α-synuclein in the brain following a specific
                      pattern (Braak et al., 2006). The relationship of this
                      pattern with motor and cognitive symptoms is still
                      equivocal. Therefore, we investigated longitudinally the
                      spatio-temporal patterns of atrophy propagation in PD, their
                      inter-individual variability and associations with clinical
                      symptoms. Magnetic resonance (MR) images of 37 PD patients
                      and 27 controls were acquired at up to 15 time-points per
                      subject, and over observation periods of up to 8.8 years
                      (mean: 3.7 years). MR images were analyzed by
                      Deformation-based Morphometry to measure region volumes and
                      their longitudinal changes. Differences of these regional
                      volume data between patients and controls and their
                      associations with clinical symptoms were calculated.},
      cin          = {INM-1 / JSC},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)JSC-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539) / HBP SGA2 - Human Brain Project
                      Specific Grant Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)945539 /
                      G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35439717},
      UT           = {WOS:000797255700003},
      doi          = {10.1016/j.cortex.2022.03.009},
      url          = {https://juser.fz-juelich.de/record/907293},
}