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| 001 | 907293 | ||
| 005 | 20230123110614.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cortex.2022.03.009 |2 doi |
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| 100 | 1 | _ | |a Pieperhoff, Peter |0 P:(DE-Juel1)131666 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Regional changes of brain structure during progression of idiopathic Parkinson's disease – A longitudinal study using deformation based morphometry |
| 260 | _ | _ | |a New York, NY |c 2022 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD are the degeneration of dopaminergic neurons in the striatum, and the propagation of aggregates of misfolded α-synuclein in the brain following a specific pattern (Braak et al., 2006). The relationship of this pattern with motor and cognitive symptoms is still equivocal. Therefore, we investigated longitudinally the spatio-temporal patterns of atrophy propagation in PD, their inter-individual variability and associations with clinical symptoms. Magnetic resonance (MR) images of 37 PD patients and 27 controls were acquired at up to 15 time-points per subject, and over observation periods of up to 8.8 years (mean: 3.7 years). MR images were analyzed by Deformation-based Morphometry to measure region volumes and their longitudinal changes. Differences of these regional volume data between patients and controls and their associations with clinical symptoms were calculated. |
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| 700 | 1 | _ | |a Hartmann, Christian J. |0 P:(DE-HGF)0 |b 3 |
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| 773 | _ | _ | |a 10.1016/j.cortex.2022.03.009 |g Vol. 151, p. 188 - 210 |0 PERI:(DE-600)2080335-7 |p 188 - 210 |t Cortex |v 151 |y 2022 |x 0010-9452 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/907293/files/Invoice_OAD0000200652.pdf |
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