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@ARTICLE{Yun:907294,
author = {Yun, Seong Dae and Pais-Roldán, Patricia and
Palomero-Gallagher, Nicola and Shah, N. J.},
title = {{M}apping of whole‐cerebrum resting‐state networks
using ultra‐high resolution acquisition protocols},
journal = {Human brain mapping},
volume = {43},
number = {11},
issn = {1065-9471},
address = {New York, NY},
publisher = {Wiley-Liss},
reportid = {FZJ-2022-01945},
pages = {3386-3403},
year = {2022},
abstract = {Resting-state functional magnetic resonance imaging (fMRI)
has been used in numerous studies to map networks in the
brain that employ spatially disparate regions. However,
attempts to map networks with high spatial resolution have
been hampered by conflicting technical demands and
associated problems. Results from recent fMRI studies have
shown that spatial resolution remains around
0.7 × 0.7 × 0.7 mm3, with only partial brain
coverage. Therefore, this work aims to present a novel fMRI
technique that was developed based on echo-planar-imaging
with keyhole (EPIK) combined with repetition-time-external
(TR-external) EPI phase correction. Each technique has been
previously shown to be effective in enhancing the spatial
resolution of fMRI, and in this work, the combination of the
two techniques into TR-external EPIK provided a nominal
spatial resolution of 0.51 × 0.51 × 1.00 mm3
(0.26 mm3 voxel) with whole-cerebrum coverage. Here, the
feasibility of using half-millimetre in-plane TR-external
EPIK for resting-state fMRI was validated using 13 healthy
subjects and the corresponding reproducible mapping of
resting-state networks was demonstrated. Furthermore,
TR-external EPIK enabled the identification of various
resting-state networks distributed throughout the brain from
a single fMRI session, with mapping fidelity onto the grey
matter at 7T. The high-resolution functional image further
revealed mesoscale anatomical structures, such as small
cerebral vessels and the internal granular layer of the
cortex within the postcentral gyrus.},
cin = {INM-1 / INM-4},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-4-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525) / Open-Access-Publikationskosten
Forschungszentrum Jülich (OAPKFZJ) (491111487)},
pid = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)491111487},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35384130},
UT = {WOS:000778741600001},
doi = {10.1002/hbm.25855},
url = {https://juser.fz-juelich.de/record/907294},
}