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000907497 1001_ $$0P:(DE-Juel1)161225$$aGenon, Sarah$$b0$$eCorresponding author
000907497 245__ $$aLinking interindividual variability in brain structure to behaviour
000907497 260__ $$aLondon$$bNature Publ. Group$$c2022
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000907497 520__ $$aWhat are the brain structural correlates of interindividual differences in behaviour? More than a decade ago, advances in structural MRI opened promising new avenues to address this question. The initial wave of research then progressively led to substantial conceptual and methodological shifts, and a replication crisis unveiled the limitations of traditional approaches, which involved searching for associations between local measurements of neuroanatomy and behavioural variables in small samples of healthy individuals. Given these methodological issues and growing scepticism regarding the idea of one-to-one mapping of psychological constructs to brain regions, new perspectives emerged. These not only embrace the multivariate nature of brain structure-behaviour relationships and promote generalizability but also embrace the representation of the relationships between brain structure and behavioural data by latent dimensions of interindividual variability. Here, we examine the past and present of the study of brain structure-behaviour associations in healthy populations and address current challenges and open questions for future investigations.
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000907497 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b1$$ufzj
000907497 7001_ $$0P:(DE-Juel1)171719$$aKharabian, Shahrzad$$b2$$ufzj
000907497 773__ $$0PERI:(DE-600)2028902-9$$a10.1038/s41583-022-00584-7$$gVol. 23, no. 5, p. 307 - 318$$n5$$p307 - 318$$tNature reviews / Neuroscience$$v23$$x1471-003X$$y2022
000907497 8564_ $$uhttps://juser.fz-juelich.de/record/907497/files/s41583-022-00584-7.pdf
000907497 8564_ $$uhttps://juser.fz-juelich.de/record/907497/files/Genon%20Author%20preprint.pdf$$yPublished on 2022-04-01. Available in OpenAccess from 2022-10-01.
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000907497 9141_ $$y2022
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