TY  - JOUR
AU  - Genon, Sarah
AU  - Eickhoff, Simon B.
AU  - Kharabian, Shahrzad
TI  - Linking interindividual variability in brain structure to behaviour
JO  - Nature reviews / Neuroscience
VL  - 23
IS  - 5
SN  - 1471-003X
CY  - London
PB  - Nature Publ. Group
M1  - FZJ-2022-02056
SP  - 307 - 318
PY  - 2022
AB  - What are the brain structural correlates of interindividual differences in behaviour? More than a decade ago, advances in structural MRI opened promising new avenues to address this question. The initial wave of research then progressively led to substantial conceptual and methodological shifts, and a replication crisis unveiled the limitations of traditional approaches, which involved searching for associations between local measurements of neuroanatomy and behavioural variables in small samples of healthy individuals. Given these methodological issues and growing scepticism regarding the idea of one-to-one mapping of psychological constructs to brain regions, new perspectives emerged. These not only embrace the multivariate nature of brain structure-behaviour relationships and promote generalizability but also embrace the representation of the relationships between brain structure and behavioural data by latent dimensions of interindividual variability. Here, we examine the past and present of the study of brain structure-behaviour associations in healthy populations and address current challenges and open questions for future investigations.
LB  - PUB:(DE-HGF)16
C6  - pmid:35365814
UR  - <Go to ISI:>//WOS:000777232500001
DO  - DOI:10.1038/s41583-022-00584-7
UR  - https://juser.fz-juelich.de/record/907497
ER  -