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@ARTICLE{Dugr:907498,
author = {Dugré, Jules R. and Eickhoff, Simon B. and Potvin,
Stéphane},
title = {{M}eta-analytical transdiagnostic neural correlates in
common pediatric psychiatric disorders},
journal = {Scientific reports},
volume = {12},
number = {1},
issn = {2045-2322},
address = {[London]},
publisher = {Macmillan Publishers Limited, part of Springer Nature},
reportid = {FZJ-2022-02057},
pages = {4909},
year = {2022},
abstract = {In the last decades, neuroimaging studies have attempted to
unveil the neurobiological markers underlying pediatric
psychiatric disorders. Yet, the vast majority of
neuroimaging studies still focus on a single nosological
category, which limit our understanding of the
shared/specific neural correlates between these disorders.
Therefore, we aimed to investigate the transdiagnostic
neural correlates through a novel and data-driven
meta-analytical method. A data-driven meta-analysis was
carried out which grouped similar experiments' topographic
map together, irrespectively of nosological categories and
task-characteristics. Then, activation likelihood estimation
meta-analysis was performed on each group of experiments to
extract spatially convergent brain regions. One hundred
forty-seven experiments were retrieved (3124 cases compared
to 3100 controls): 79 attention-deficit/hyperactivity
disorder, 32 conduct/oppositional defiant disorder, 14
anxiety disorders, 22 major depressive disorders. Four
significant groups of experiments were observed. Functional
characterization suggested that these groups of aberrant
brain regions may be implicated internally/externally
directed processes, attentional control of affect,
somato-motor and visual processes. Furthermore, despite that
some differences in rates of studies involving major
depressive disorders were noticed, nosological categories
were evenly distributed between these four sets of regions.
Our results may reflect transdiagnostic neural correlates of
pediatric psychiatric disorders, but also underscore the
importance of studying pediatric psychiatric disorders
simultaneously rather than independently to examine
differences between disorders.},
cin = {INM-7},
ddc = {600},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35318371},
UT = {WOS:000772185000060},
doi = {10.1038/s41598-022-08909-3},
url = {https://juser.fz-juelich.de/record/907498},
}