%0 Journal Article
%A Pais, Patricia
%A Yun, Seong Dae
%A Shah, N. Jon
%T Pre-processing of Sub-millimeter GE-BOLD fMRI Data for Laminar Applications
%J Frontiers in neuroimaging
%V 1
%@ 2813-1193
%C Lausanne
%I Frontiers Media SA
%M FZJ-2022-02079
%P 869454
%D 2022
%X Over the past 30 years, brain function has primarily been evaluated non-invasively using functional magnetic resonance imaging (fMRI) with gradient-echo (GE) sequences to measure blood-oxygen-level-dependent (BOLD) signals. Despite the multiple advantages of GE sequences, e.g., higher signal-to-noise ratio, faster acquisitions, etc., their relatively inferior spatial localization compromises the routine use of GE-BOLD in laminar applications. Here, in an attempt to rescue the benefits of GE sequences, we evaluated the effect of existing pre-processing methods on the spatial localization of signals obtained with EPIK, a GE sequence that affords voxel volumes of 0.25 mm3 with near whole-brain coverage. The methods assessed here apply to both task and resting-state fMRI data assuming the availability of reconstructed magnitude and phase images.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 37555171
%U <Go to ISI:>//WOS:001537169300001
%R 10.3389/fnimg.2022.869454
%U https://juser.fz-juelich.de/record/907552