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000907657 1001_ $$00000-0002-8231-5895$$aMarjault, Henri-Baptiste$$b0
000907657 245__ $$aAn anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters
000907657 260__ $$aLondon$$bSpringer Nature$$c2022
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000907657 520__ $$aElevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the progression of diabetes, negatively impacting insulin production and secretion from pancreatic cells. In search for a tool to reduce mitochondrial iron and ROS levels, we arrived at a molecule that destabilizes the [2Fe-2S] clusters of NEET proteins (M1). Treatment of db/db diabetic mice with M1 improved hyperglycemia, without the weight gain observed with alternative treatments such as rosiglitazone. The molecular interactions of M1 with the NEET proteins mNT and NAF-1 were determined by X-crystallography. The possibility of controlling diabetes by molecules that destabilize the [2Fe–2S] clusters of NEET proteins, thereby reducing iron-mediated oxidative stress, opens a new route for managing metabolic aberration such as in diabetes.
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000907657 7001_ $$0P:(DE-HGF)0$$aKarmi, Ola$$b1
000907657 7001_ $$0P:(DE-HGF)0$$aZuo, Ke$$b2
000907657 7001_ $$0P:(DE-HGF)0$$aMichaeli, Dorit$$b3
000907657 7001_ $$0P:(DE-HGF)0$$aEisenberg-Domovich, Yael$$b4
000907657 7001_ $$0P:(DE-Juel1)145921$$aRossetti, Giulia$$b5
000907657 7001_ $$00000-0002-7488-8597$$ade Chassey, Benoit$$b6
000907657 7001_ $$0P:(DE-HGF)0$$aVonderscher, Jacky$$b7
000907657 7001_ $$0P:(DE-HGF)0$$aCabantchik, Ioav$$b8
000907657 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b9$$ufzj
000907657 7001_ $$0P:(DE-HGF)0$$aMittler, Ron$$b10
000907657 7001_ $$00000-0002-8682-2106$$aLivnah, Oded$$b11
000907657 7001_ $$0P:(DE-HGF)0$$aMeldrum, Eric$$b12
000907657 7001_ $$00000-0002-3219-954X$$aNechushtai, Rachel$$b13$$eCorresponding author
000907657 773__ $$0PERI:(DE-600)2919698-X$$a10.1038/s42003-022-03393-x$$gVol. 5, no. 1, p. 437$$n1$$p437$$tCommunications biology$$v5$$x2399-3642$$y2022
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