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@ARTICLE{Marjault:907657,
      author       = {Marjault, Henri-Baptiste and Karmi, Ola and Zuo, Ke and
                      Michaeli, Dorit and Eisenberg-Domovich, Yael and Rossetti,
                      Giulia and de Chassey, Benoit and Vonderscher, Jacky and
                      Cabantchik, Ioav and Carloni, Paolo and Mittler, Ron and
                      Livnah, Oded and Meldrum, Eric and Nechushtai, Rachel},
      title        = {{A}n anti-diabetic drug targets {NEET} ({CISD}) proteins
                      through destabilization of their [2{F}e-2{S}] clusters},
      journal      = {Communications biology},
      volume       = {5},
      number       = {1},
      issn         = {2399-3642},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2022-02136},
      pages        = {437},
      year         = {2022},
      abstract     = {Elevated levels of mitochondrial iron and reactive oxygen
                      species (ROS) accompany the progression of diabetes,
                      negatively impacting insulin production and secretion from
                      pancreatic cells. In search for a tool to reduce
                      mitochondrial iron and ROS levels, we arrived at a molecule
                      that destabilizes the [2Fe-2S] clusters of NEET proteins
                      (M1). Treatment of db/db diabetic mice with M1 improved
                      hyperglycemia, without the weight gain observed with
                      alternative treatments such as rosiglitazone. The molecular
                      interactions of M1 with the NEET proteins mNT and NAF-1 were
                      determined by X-crystallography. The possibility of
                      controlling diabetes by molecules that destabilize the
                      [2Fe–2S] clusters of NEET proteins, thereby reducing
                      iron-mediated oxidative stress, opens a new route for
                      managing metabolic aberration such as in diabetes.},
      cin          = {IAS-5 / INM-9 / JSC},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121 /
                      I:(DE-Juel1)JSC-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5111 -
                      Domain-Specific Simulation $\&$ Data Life Cycle Labs (SDLs)
                      and Research Groups (POF4-511)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5111},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35538231},
      UT           = {WOS:000793196800001},
      doi          = {10.1038/s42003-022-03393-x},
      url          = {https://juser.fz-juelich.de/record/907657},
}