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| 024 | 7 | _ | |a 10.1038/s42003-022-03393-x |2 doi |
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| 100 | 1 | _ | |a Marjault, Henri-Baptiste |0 0000-0002-8231-5895 |b 0 |
| 245 | _ | _ | |a An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters |
| 260 | _ | _ | |a London |c 2022 |b Springer Nature |
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| 520 | _ | _ | |a Elevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the progression of diabetes, negatively impacting insulin production and secretion from pancreatic cells. In search for a tool to reduce mitochondrial iron and ROS levels, we arrived at a molecule that destabilizes the [2Fe-2S] clusters of NEET proteins (M1). Treatment of db/db diabetic mice with M1 improved hyperglycemia, without the weight gain observed with alternative treatments such as rosiglitazone. The molecular interactions of M1 with the NEET proteins mNT and NAF-1 were determined by X-crystallography. The possibility of controlling diabetes by molecules that destabilize the [2Fe–2S] clusters of NEET proteins, thereby reducing iron-mediated oxidative stress, opens a new route for managing metabolic aberration such as in diabetes. |
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| 700 | 1 | _ | |a Meldrum, Eric |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Nechushtai, Rachel |0 0000-0002-3219-954X |b 13 |e Corresponding author |
| 773 | _ | _ | |a 10.1038/s42003-022-03393-x |g Vol. 5, no. 1, p. 437 |0 PERI:(DE-600)2919698-X |n 1 |p 437 |t Communications biology |v 5 |y 2022 |x 2399-3642 |
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