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000907897 1001_ $$00000-0002-3825-399X$$aWinter, Johanna$$b0$$eCorresponding author
000907897 245__ $$aHeat management of a compact x‐ray source for microbeam radiotherapy and FLASH treatments
000907897 260__ $$aCollege Park, Md.$$bAAPM$$c2022
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000907897 520__ $$aBackground:Microbeam and x-ray FLASH radiation therapy are innovativeconcepts that promise reduced normal tissue toxicity in radiation oncology withoutcompromising tumor control. However, currently only large third-generationsynchrotrons deliver acceptable x-ray beam qualities and there is a need forcompact, hospital-based radiation sources to facilitate clinical translation ofthese novel treatment strategies.Purpose: We are currently setting up the first prototype of a line-focus x-raytube (LFxT), a promising technology that may deliver ultra-high dose rates(UHDRs) of more than 100 Gy/s from a table-top source. The operation of thesource in the heat capacity limit allows very high dose rates with micrometersizedfocal spot widths.Here,we investigate concepts of effective heat managementfor the LFxT, a prerequisite for the performance of the source.Methods: For different focal spot widths, we investigated the temperatureincrease numerically with Monte Carlo simulations and finite element analysis(FEA).We benchmarked the temperature and thermal stresses at the focal spotagainst a commercial x-ray tube with similar power characteristics.We assessedthermal loads at the vacuum chamber housing caused by scattering electrons inMonte Carlo simulations and FEA. Further,we discuss active cooling strategiesand present a design of the rotating target.
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000907897 536__ $$0G:(GEPRIS)416790481$$aDFG project 416790481 - Tumortherapie mit Mikrostrahlen an kompakter Strahlenquelle (416790481)$$c416790481$$x1
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000907897 7001_ $$0P:(DE-Juel1)180572$$aDimroth, Anton$$b1$$eCorresponding author
000907897 7001_ $$0P:(DE-HGF)0$$aRoetzer, Sebastian$$b2
000907897 7001_ $$0P:(DE-HGF)0$$aZhang, Yunzhe$$b3
000907897 7001_ $$0P:(DE-HGF)0$$aKrämer, Karl-Ludwig$$b4
000907897 7001_ $$00000-0002-5002-4719$$aPetrich, Christian$$b5
000907897 7001_ $$0P:(DE-HGF)0$$aMatejcek, Christoph$$b6
000907897 7001_ $$0P:(DE-HGF)0$$aAulenbacher, Kurt$$b7
000907897 7001_ $$0P:(DE-HGF)0$$aZimmermann, Markus$$b8
000907897 7001_ $$00000-0002-6934-2864$$aCombs, Stephanie E.$$b9
000907897 7001_ $$00000-0002-6983-9758$$aGalek, Marek$$b10
000907897 7001_ $$0P:(DE-Juel1)142196$$aNatour, Ghaleb$$b11
000907897 7001_ $$0P:(DE-Juel1)133642$$aButzek, Michael$$b12
000907897 7001_ $$00000-0002-1851-0581$$aWilkens, Jan J.$$b13
000907897 7001_ $$00000-0001-9550-9122$$aBartzsch, Stefan$$b14
000907897 773__ $$0PERI:(DE-600)1466421-5$$a10.1002/mp.15611$$gVol. 49, no. 5, p. 3375 - 3388$$n5$$p3375 - 3388$$tMedical physics$$v49$$x0094-2405$$y2022
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