TY  - JOUR
AU  - Winter, Johanna
AU  - Dimroth, Anton
AU  - Roetzer, Sebastian
AU  - Zhang, Yunzhe
AU  - Krämer, Karl-Ludwig
AU  - Petrich, Christian
AU  - Matejcek, Christoph
AU  - Aulenbacher, Kurt
AU  - Zimmermann, Markus
AU  - Combs, Stephanie E.
AU  - Galek, Marek
AU  - Natour, Ghaleb
AU  - Butzek, Michael
AU  - Wilkens, Jan J.
AU  - Bartzsch, Stefan
TI  - Heat management of a compact x‐ray source for microbeam radiotherapy and FLASH treatments
JO  - Medical physics
VL  - 49
IS  - 5
SN  - 0094-2405
CY  - College Park, Md.
PB  - AAPM
M1  - FZJ-2022-02275
SP  - 3375 - 3388
PY  - 2022
AB  - Background:Microbeam and x-ray FLASH radiation therapy are innovativeconcepts that promise reduced normal tissue toxicity in radiation oncology withoutcompromising tumor control. However, currently only large third-generationsynchrotrons deliver acceptable x-ray beam qualities and there is a need forcompact, hospital-based radiation sources to facilitate clinical translation ofthese novel treatment strategies.Purpose: We are currently setting up the first prototype of a line-focus x-raytube (LFxT), a promising technology that may deliver ultra-high dose rates(UHDRs) of more than 100 Gy/s from a table-top source. The operation of thesource in the heat capacity limit allows very high dose rates with micrometersizedfocal spot widths.Here,we investigate concepts of effective heat managementfor the LFxT, a prerequisite for the performance of the source.Methods: For different focal spot widths, we investigated the temperatureincrease numerically with Monte Carlo simulations and finite element analysis(FEA).We benchmarked the temperature and thermal stresses at the focal spotagainst a commercial x-ray tube with similar power characteristics.We assessedthermal loads at the vacuum chamber housing caused by scattering electrons inMonte Carlo simulations and FEA. Further,we discuss active cooling strategiesand present a design of the rotating target.
LB  - PUB:(DE-HGF)16
C6  - pmid:35315089
UR  - <Go to ISI:>//WOS:000778971300001
DO  - DOI:10.1002/mp.15611
UR  - https://juser.fz-juelich.de/record/907897
ER  -