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@ARTICLE{Winter:907897,
      author       = {Winter, Johanna and Dimroth, Anton and Roetzer, Sebastian
                      and Zhang, Yunzhe and Krämer, Karl-Ludwig and Petrich,
                      Christian and Matejcek, Christoph and Aulenbacher, Kurt and
                      Zimmermann, Markus and Combs, Stephanie E. and Galek, Marek
                      and Natour, Ghaleb and Butzek, Michael and Wilkens, Jan J.
                      and Bartzsch, Stefan},
      title        = {{H}eat management of a compact x‐ray source for microbeam
                      radiotherapy and {FLASH} treatments},
      journal      = {Medical physics},
      volume       = {49},
      number       = {5},
      issn         = {0094-2405},
      address      = {College Park, Md.},
      publisher    = {AAPM},
      reportid     = {FZJ-2022-02275},
      pages        = {3375 - 3388},
      year         = {2022},
      abstract     = {Background:Microbeam and x-ray FLASH radiation therapy are
                      innovativeconcepts that promise reduced normal tissue
                      toxicity in radiation oncology withoutcompromising tumor
                      control. However, currently only large
                      third-generationsynchrotrons deliver acceptable x-ray beam
                      qualities and there is a need forcompact, hospital-based
                      radiation sources to facilitate clinical translation ofthese
                      novel treatment strategies.Purpose: We are currently setting
                      up the first prototype of a line-focus x-raytube (LFxT), a
                      promising technology that may deliver ultra-high dose
                      rates(UHDRs) of more than 100 Gy/s from a table-top source.
                      The operation of thesource in the heat capacity limit allows
                      very high dose rates with micrometersizedfocal spot
                      widths.Here,we investigate concepts of effective heat
                      managementfor the LFxT, a prerequisite for the performance
                      of the source.Methods: For different focal spot widths, we
                      investigated the temperatureincrease numerically with Monte
                      Carlo simulations and finite element analysis(FEA).We
                      benchmarked the temperature and thermal stresses at the
                      focal spotagainst a commercial x-ray tube with similar power
                      characteristics.We assessedthermal loads at the vacuum
                      chamber housing caused by scattering electrons inMonte Carlo
                      simulations and FEA. Further,we discuss active cooling
                      strategiesand present a design of the rotating target.},
      cin          = {ZEA-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ZEA-1-20090406},
      pnm          = {899 - ohne Topic (POF4-899) / DFG project 416790481 -
                      Tumortherapie mit Mikrostrahlen an kompakter Strahlenquelle
                      (416790481)},
      pid          = {G:(DE-HGF)POF4-899 / G:(GEPRIS)416790481},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35315089},
      UT           = {WOS:000778971300001},
      doi          = {10.1002/mp.15611},
      url          = {https://juser.fz-juelich.de/record/907897},
}