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001     907897
005     20250701125854.0
024 7 _ |a 10.1002/mp.15611
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037 _ _ |a FZJ-2022-02275
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100 1 _ |a Winter, Johanna
|0 0000-0002-3825-399X
|b 0
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245 _ _ |a Heat management of a compact x‐ray source for microbeam radiotherapy and FLASH treatments
260 _ _ |a College Park, Md.
|c 2022
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520 _ _ |a Background:Microbeam and x-ray FLASH radiation therapy are innovativeconcepts that promise reduced normal tissue toxicity in radiation oncology withoutcompromising tumor control. However, currently only large third-generationsynchrotrons deliver acceptable x-ray beam qualities and there is a need forcompact, hospital-based radiation sources to facilitate clinical translation ofthese novel treatment strategies.Purpose: We are currently setting up the first prototype of a line-focus x-raytube (LFxT), a promising technology that may deliver ultra-high dose rates(UHDRs) of more than 100 Gy/s from a table-top source. The operation of thesource in the heat capacity limit allows very high dose rates with micrometersizedfocal spot widths.Here,we investigate concepts of effective heat managementfor the LFxT, a prerequisite for the performance of the source.Methods: For different focal spot widths, we investigated the temperatureincrease numerically with Monte Carlo simulations and finite element analysis(FEA).We benchmarked the temperature and thermal stresses at the focal spotagainst a commercial x-ray tube with similar power characteristics.We assessedthermal loads at the vacuum chamber housing caused by scattering electrons inMonte Carlo simulations and FEA. Further,we discuss active cooling strategiesand present a design of the rotating target.
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536 _ _ |a DFG project 416790481 - Tumortherapie mit Mikrostrahlen an kompakter Strahlenquelle (416790481)
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700 1 _ |a Dimroth, Anton
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700 1 _ |a Roetzer, Sebastian
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700 1 _ |a Zhang, Yunzhe
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700 1 _ |a Krämer, Karl-Ludwig
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700 1 _ |a Petrich, Christian
|0 0000-0002-5002-4719
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700 1 _ |a Matejcek, Christoph
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700 1 _ |a Aulenbacher, Kurt
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700 1 _ |a Zimmermann, Markus
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700 1 _ |a Combs, Stephanie E.
|0 0000-0002-6934-2864
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700 1 _ |a Galek, Marek
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700 1 _ |a Natour, Ghaleb
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700 1 _ |a Butzek, Michael
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700 1 _ |a Wilkens, Jan J.
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700 1 _ |a Bartzsch, Stefan
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773 _ _ |a 10.1002/mp.15611
|g Vol. 49, no. 5, p. 3375 - 3388
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|t Medical physics
|v 49
|y 2022
|x 0094-2405
856 4 _ |u https://juser.fz-juelich.de/record/907897/files/Medical%20Physics%20-%202022%20-%20Winter%20-%20Heat%20management%20of%20a%20compact%20x%E2%80%90ray%20source%20for%20microbeam%20radiotherapy%20and%20FLASH%20treatments.pdf
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