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@MISC{Lohmann:908193,
      author       = {Lohmann, Philipp and Piroth, Marc D and Sellhaus, Bernd and
                      Geisler, Stefanie and Oros-Peusquens, Ana-Maria and
                      Mohlberg, Hartmut and Amunts, Katrin and Shah, Nadim J and
                      Galldiks, Norbert and Langen, Karl-Josef},
      title        = {{NIMG}-78. {FIRST} {TIME} {CORRELATION} {OF} {FET} {PET},
                      {MRI} {AND} {POST}-{MORTEM} {WHOLE}-{BRAIN} {HISTOPATHOLOGY}
                      {IN} {A} {PROGRESSIVE} {GLIOBLASTOMA}},
      issn         = {1523-5866},
      reportid     = {FZJ-2022-02446},
      year         = {2017},
      abstract     = {BACKGROUND Amino acid PET using
                      O-(2-[18F]fluoroethyl)-L-tyrosine (FET) provides important
                      additional information on the extent of viable tumor tissue
                      of glioblastoma compared with MRI. Especially after
                      radiochemotherapy, progression of contrast enhancement in
                      MRI can be equivocal and may represent either true tumor
                      progression or treatment-related changes. We present the
                      first case comparing post-mortem whole-brain histopathology
                      in progressive glioblastoma with dynamic in vivo FET PET and
                      MRI.METHODSA 61-year-old glioblastoma patient underwent
                      initially partial resection and died eleven weeks after
                      completion of chemoradiation with concurrent temozolomide.
                      Three days before the patient died, a follow-up FET PET and
                      MRI scan indicated local tumor progression within the
                      irradiation field. An autopsy was performed at 48 h hours
                      after death and the tumor bearing brain was preserved. After
                      fixation in formalin and paraffin embedding, the brain
                      tissue was cut into 3500 coronal sections (20 micrometers).
                      Representative sections were stained using GFAP and cresyl
                      violet. An experienced neuropathologist identified areas of
                      neoplastic tissue, astrogliosis and necrosis. In vivo FET
                      PET, MRI and histopathology were co-registered and compared
                      by three experienced physicians.RESULTSIncreased FET uptake
                      (tumor-to-brain ratio = 2.3) in the area of equivocal
                      contrast enhancement on MRI correlated very well with vital
                      tumor cells and showed tracer kinetics typical for malignant
                      gliomas (early peak followed by constant descent). An area
                      of reactive astrogliosis showed only moderate FET uptake
                      (tumor-to-brain ratio = 1.5) and tracer kinetics usually
                      observed in benign lesions (constantly increasing). Necrotic
                      areas showed neither enhanced FET uptake nor contrast
                      enhancement in MRI.CONCLUSIONSThis case report documents for
                      the first time the correct imaging of a progressive
                      glioblastoma by FET PET, thereby confirming findings from
                      previous studies. FET PET significantly contributes to the
                      correct identification of neoplastic tissue and, thus, to a
                      better differentiation of tumor progression and
                      treatment-related changes.},
      cin          = {INM-4 / INM-11 / INM-1 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)4},
      doi          = {10.1093/neuonc/nox168.650},
      url          = {https://juser.fz-juelich.de/record/908193},
}